Publications – Prof. Dr. Peter J. Flor

Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7.
Ullmer C, Zoffmann S, Bohrmann B, Matile BH, Lindemann L, Flor PJ, Malherbe P.
British Journal of Pharmacology. 2012; in press. IF=4.4

Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs.
Flor PJ, Acher FC.
Biochemical Pharmacology. 2012; in press. IF=4.7

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear.
Toth I, Dietz M, Peterlik D, Huber SE, Fendt M, Neumann ID, Flor PJ, Slattery DA.
Neuropharmacology. 2012 Mar;62(4):1619-26. IF=4.8

Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.
Bahi A, Fizia K, Dietz M, Gasparini F, Flor PJ.
Addict Biol. 2012 Mar;17(2):235-47. IF=4.8

Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues.
Julio-Pieper M, Flor PJ, Dinan TG, Cryan JF.
Pharmacol Rev. 2011 Mar;63(1):35-58. IF=20.2
PMID: 21228260

Metabotropic glutamate receptor 7: at the interface of cognition and emotion.
O'Connor RM, Finger BC, Flor PJ, Cryan JF.
Eur J Pharmacol. 2010 Aug 10;639(1-3):123-31. IF=2.7
PMID: 20371242 

Antisense oligonucleotides.
Neumann ID, Flor PJ.
Encyclopedia of Psychopharmacology. 2010, Ian P. Stolerman (ed.), Springer-Verlag Berlin Heidelberg 2010.  

Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Greco B, Lopez S, van der Putten H, Flor PJ, Amalric M.
J Pharmacol Exp Ther. 2010 Mar;332(3):1064-71. IF=4.0
PMID: 19940105 

Publications before coming to Regensburg:
Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission.
Stachowicz K, Brañski P, Kłak K, van der Putten H, Cryan JF, Flor PJ, Andrzej P.
Behav Pharmacol. 2008 Sep;19(5-6):597-603.
PMID: 18690114  

Amygdaloid metabotropic glutamate receptor subtype 7 is involved in the acquisition of conditioned fear.
Siegl S, Flor PJ, Fendt M.
Neuroreport. 2008 Jul 16;19(11):1147-50.
PMID: 18596617  

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.
Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ.
Mol Psychiatry. 2008 Oct;13(10):970-9. IF=12.5  
PMID: 17712315

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice.
Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A.
Psychopharmacology (Berl). 2007 Nov;194(4):555-62.  
PMID: 17622518 ]

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H, Becker AJ.
Neurobiol Dis. 2007 Jun;26(3):623-33.  
PMID: 17446080  

Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking.
Zeitz C, Forster U, Neidhardt J, Feil S, Kälin S, Leifert D, Flor PJ, Berger W.
Hum Mutat. 2007 Aug;28(8):771-80.
PMID: 17405131  ]

Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R.
Bioorg Med Chem. 2007 May 1;15(9):3161-70.  
PMID: 17350267  

Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders.
Hoyer D, Thakker DR, Natt F, Maier R, Huesken D, Müller M, Flor P, VAN DER Putten H, Schmutz M, Bilbe G, Cryan JF.
J Recept Signal Transduct Res. 2006;26(5-6):527-47.
PMID: 17118797  

Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders.
Mitsukawa K, Mombereau C, Lötscher E, Uzunov DP, van der Putten H, Flor PJ, Cryan JF.
Neuropsychopharmacology. 2006 Jun;31(6):1112-22.
PMID: 16237391 

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N, Mombereau C, Kuhn R, McAllister KH, van der Putten H, Cryan JF, Flor PJ.
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. IF=10.2   
PMID: 16339898  

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.
Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ.
Neuropharmacology. 2003 Dec;45(7):895-906.
PMID: 14573382  

Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7.
Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H.
Eur J Neurosci. 2003 Jun;17(11):2409-17.
PMID: 12814372  

Neuroprotective activity of metabotropic glutamate receptor ligands.
Flor PJ, Battaglia G, Nicoletti F, Gasparini F, Bruno V.
Adv Exp Med Biol. 2002;513:197-223. Review.
PMID: 12575822  

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.
Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor PJ, Lingenhöhl K, Spooren W, Gentsch C, Vassout A, Pilc A, Gasparini F.
Amino Acids. 2002;23(1-3):207-11. Review.
PMID: 12373539  

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
Gasparini F, Andres H, Flor PJ, Heinrich M, Inderbitzin W, Lingenhöhl K, Müller H, Munk VC, Omilusik K, Stierlin C, Stoehr N, Vranesic I, Kuhn R.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9.
PMID: 11814808  

Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Sansig G, Bushell TJ, Clarke VR, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor PJ, Kuhn R, Knoepfel T, Schroeder M, Hampson DR, Collett VJ, Zhang C, Duvoisin RM, Collingridge GL, van Der Putten H.
J Neurosci. 2001 Nov 15;21(22):8734-45.
PMID: 11698585  

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs.
Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F.
J Cereb Blood Flow Metab. 2001 Sep;21(9):1013-33. Review.
PMID: 11524608

Discovery and characterization of non-competitive antagonists of group I metabotropic glutamate receptors.
Gasparini F, Floersheim P, Flor PJ, Heinrich M, Inderbitzin W, Ott D, Pagano A, Stierlin C, Stoehr N, Vranesic I, Kuhn R.
Farmaco. 2001 Jan-Feb;56(1-2):95-9. Review.
PMID: 11347975  

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
Bruno V, Battaglia G, Copani A, Cespédes VM, Galindo MF, Ceña V, Sánchez-Prieto J, Gasparini F, Kuhn R, Flor PJ, Nicoletti F.
Eur J Neurosci. 2001 Apr;13(8):1469-78.
PMID: 11328342  

Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.
Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F.
J Med Chem. 2000 Nov 16;43(23):4428-36.
PMID: 11087567  

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.
Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R.
Neuropharmacology. 2001;40(1):1-9.
PMID: 11077065  

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective.
Bruno V, Ksiazek I, Battaglia G, Lukic S, Leonhardt T, Sauer D, Gasparini F, Kuhn R, Nicoletti F, Flor PJ.
Neuropharmacology. 2000 Sep;39(12):2223-30.
PMID: 10974306  

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Bruno V, Battaglia G, Ksiazek I, van der Putten H, Catania MV, Giuffrida R, Lukic S, Leonhardt T, Inderbitzin W, Gasparini F, Kuhn R, Hampson DR, Nicoletti F, Flor PJ.
J Neurosci. 2000 Sep 1;20(17):6413-20.
PMID: 10964947

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
Pagano A, Ruegg D, Litschig S, Stoehr N, Stierlin C, Heinrich M, Floersheim P, Prezèau L, Carroll F, Pin JP, Cambria A, Vranesic I, Flor PJ, Gasparini F, Kuhn R.
J Biol Chem. 2000 Oct 27;275(43):33750-8.
PMID: 10934211

Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.
Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I.
Bioorg Med Chem Lett. 2000 Jul 3;10(13):1447-50.
PMID: 10888329  

(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.
Gasparini F, Inderbitzin W, Francotte E, Lecis G, Richert P, Dragic Z, Kuhn R, Flor PJ.
Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4.
PMID: 10866390  

Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage.
Henrich-Noack P, Flor PJ, Sabelhaus CF, Prass K, Dirnagl U, Gasparini F, Sauter A, Rudin M, Reymann KG.
Neuropharmacology. 2000 Mar 3;39(5):911-7.
PMID: 10699457  

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Gasparini F, Lingenhöhl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Veliçelebi G, Kuhn R.
Neuropharmacology. 1999 Oct;38(10):1493-503.
PMID: 10530811  

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC.
J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.
PMID: 10381773

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D, Sommer B, Varney MA, Hess SD, Johnson EC, Kuhn R, Urwyler S, Sauer D, Portet C, Schmutz M, Nicoletti F, Flor PJ.
J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87.
PMID: 10336568

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prézeau L, Pin JP, Thomsen C, Kuhn R.
Mol Pharmacol. 1999 Mar;55(3):453-61.
PMID: 10051528  

Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system.
Weng K, Lu C, Daggett LP, Kuhn R, Flor PJ, Johnson EC, Robinson PR.
J Biol Chem. 1997 Dec 26;272(52):33100-4.
PMID: 9407094  

Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N.
J Neurosci. 1997 Oct 1;17(19):7503-22.
PMID: 9295396  

Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype.
Lin FF, Varney M, Sacaan AI, Jachec C, Daggett LP, Rao S, Flor P, Kuhn R, Kerner JA, Standaert D, Young AB, Veliçelebi G.
Neuropharmacology. 1997 Jul;36(7):917-31.
PMID: 9257936  

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B.
Nature. 1997 Mar 20;386(6622):239-46.
PMID: 9069281  

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b.
Flor PJ, Van Der Putten H, Rüegg D, Lukic S, Leonhardt T, Bence M, Sansig G, Knöpfel T, Kuhn R.
Neuropharmacology. 1997 Feb;36(2):153-9.
PMID: 9144652  

The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.
Flor PJ, Gomeza J, Tones MA, Kuhn R, Pin JP, Knöpfel T.
J Neurochem. 1996 Jul;67(1):58-63.
PMID: 8667026  

The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.
Tones MA, Bendali N, Flor PJ, Knöpfel T, Kuhn R.
Neuroreport. 1995 Dec 29;7(1):117-20.
PMID: 8742431  

Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes.
Knöpfel T, Lukic S, Leonard T, Flor PJ, Kuhn R, Gasparini F.
Neuropharmacology. 1995 Aug;34(8):1099-102.
PMID: 8532159  

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
Flor PJ, Lindauer K, Püttner I, Rüegg D, Lukic S, Knöpfel T, Kuhn R.
Eur J Neurosci. 1995 Apr 1;7(4):622-9.
PMID: 7620613

Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a.
Knöpfel T, Sakaki J, Flor PJ, Baumann P, Sacaan AI, Veliçelebi G, Kuhn R, Allgeier H.
Eur J Pharmacol. 1995 Feb 15;288(3):389-92.
PMID: 7774685  

Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4.
Flor PJ, Lukic S, Rüegg D, Leonhardt T, Knöpfel T, Kuhn R.
Neuropharmacology. 1995 Feb;34(2):149-55.
PMID: 7617140  

Characterization of the Antirrhinum floral homeotic MADS-box gene deficiens: evidence for DNA binding and autoregulation of its persistent expression throughout flower development.
Schwarz-Sommer Z, Hue I, Huijser P, Flor PJ, Hansen R, Tetens F, Lönnig WE, Saedler H, Sommer H.
EMBO J. 1992 Jan;11(1):251-63.
PMID: 1346760  

Properties of deficiens, a homeotic gene involved in the control of flower morphogenesis in Antirrhinum-majus.
Sommer H, Nacken W, Beltran P, Huijser P, Pape H, Hansen R, Flor P, Saedler H, Schwarz-Sommer Z.
DEVELOPMENT. 1991 Supplement (1):169-75.
Accession Number: WOS:A1991GA05000019 

A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.
Flor PJ, Flanegan JB, Cech TR.
EMBO J. 1989 Nov;8(11):3391-9.
PMID: 2684642