Most relevant recent Publications (year 2000 until present)

Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs.
Flor PJ, Acher FC.
Biochem Pharmacol. 2012 Apr 24; in press.
PMID: 22554564 (PDF file)

Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear.
Toth I, Dietz M, Peterlik D, Huber SE, Fendt M, Neumann ID, Flor PJ, Slattery DA.
Neuropharmacology. 2012 Mar;62(4):1619-26.
PMID: 22079159 (PDF file)

Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats.
Bahi A, Fizia K, Dietz M, Gasparini F, Flor PJ.
Addict Biol. 2012 Mar;17(2):235-47.
PMID: 21392179 (PDF file)

Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues.
Julio-Pieper M, Flor PJ, Dinan TG, Cryan JF.
Pharmacol Rev. 2011 Mar;63(1):35-58.
PMID: 21228260 (PDF file)

Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Greco B, Lopez S, van der Putten H, Flor PJ, Amalric M.
J Pharmacol Exp Ther. 2010 Mar;332(3):1064-71.
PMID:19940105 (PDF file)

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.
Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ.
Mol Psychiatry. 2008 Oct;13(10):970-9.  
PMID: 17712315 (PDF file)

Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders.
Mitsukawa K, Mombereau C, Lötscher E, Uzunov DP, van der Putten H, Flor PJ, Cryan JF.
Neuropsychopharmacology. 2006 Jun;31(6):1112-22.
PMID: 16237391 (PDF file)

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N, Mombereau C, Kuhn R, McAllister KH, van der Putten H, Cryan JF, Flor PJ.
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7.  
PMID: 16339898 (PDF file)

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.
Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ.
Neuropharmacology. 2003 Dec;45(7):895-906.
PMID: 14573382 (PDF file)
Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7.
Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H.
Eur J Neurosci. 2003 Jun;17(11):2409-17.
PMID: 12814372 (PDF file)

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective.
Bruno V, Ksiazek I, Battaglia G, Lukic S, Leonhardt T, Sauer D, Gasparini F, Kuhn R, Nicoletti F, Flor PJ.
Neuropharmacology. 2000 Sep;39(12):2223-30.
PMID: 10974306 (PDF file)

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Bruno V, Battaglia G, Ksiazek I, van der Putten H, Catania MV, Giuffrida R, Lukic S, Leonhardt T, Inderbitzin W, Gasparini F, Kuhn R, Hampson DR, Nicoletti F, Flor PJ.
J Neurosci. 2000 Sep 1;20(17):6413-20.
PMID: 10964947 (PDF file)