Prof. Dr. Christoph Klein
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Address |
Division of Oncogenomics
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Department of Pathology |
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University Hospital Regensburg |
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Franz-Josef-Strauss-Allee 11 |
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93053 Regensburg |
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| Phone |
++49 (0) 941 944 6720 |
| Fax |
++49 (0) 941 944 6719 |
| e-mail |
christoph.klein [at] klinik.uni-regensburg.de |
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| Homepage |
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Research Interests
- Identification of metastasis founder cells
- Analysis of systemic cancer progression
- Identification of novel drug targets for systemic cancer therapy
- Analysis of migrating cancer stem cells
- Development of models of cancer progression
- Development and application of single-cell technologies
Curriculum Vitae
| Education |
| 1988 - 1995 |
Study of Human Medicine; Ludwig-Maximilians-Universität, Munich, University of Toronto, Toronto, Canada, and Lousiana State University,
New Orleans, USA |
| Scientific Career |
| 1994 - 1995 |
6-month research stay at the Ontario Cancer Institute, Torornto (Prof.
Tak W. Mak) with a fellowship of the Boehringer Ingelheim Fonds |
| 1998 |
Conferral of doctorate (Dr. med., summa cum laude); Institute for Immunology, Ludwig-Maximilians-Universität, Munich (Prof. Dr. Gert Riethmüller); Title: Enrichment and molecular characterization of single disseminated tumor cells in the bone marrow of carcinoma patients |
| 1998 - 2001 |
Group leader "Molecular genetic analysis of minimal residual cancer disease", Institute for Immunology, Ludwig-Maximilians-Universität,
Munich |
| since 2001 |
Group leader of a BioFuture junior research group |
| 2004 |
Habilitation in Immunology, Ludwig-Maximilians-Universität, Munich |
| July 2004 |
Group leader of a junior research group of the Bavarian Genome Research Network (BayGene) |
| Feb 2007 |
Call for a professorship for Oncogenomics, University of Regensburg |
| May 2007 - |
W2-professor for Oncogenomics, University of Regensburg |
| Awards |
| 1999 |
Curt-Bohnewand Prize of the Ludwig-Maximilians-Universität, Munich |
| 2001 |
Prize Winner of the BioFuture junior research groups competition |
| 2007 |
Prostate Cancer Foundation Award |
| Other |
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| 2004 |
Supported as a junior research group during the competition for participation in the bavarian genome research network (BayGene) |
| Publications |
Impact factor |
| Weckermann D, Polzer B, Ragg T, Blana A, Schlimok G, Arnholdt H, Bertz S, Harzmann R, Klein CA: Perioperative Activation of Disseminated Tumor Cells in Bone Marrow of Patients with Prostate Cancer J Clin Oncol, in press |
15,4 |
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| Klein CA: Cancer. The metastasis cascade. Science 321:1785-7, 2008 |
26,3 |
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| Stoecklein NH, Hosch SB, Bezler M, Stern F, Hartmann CH, Vay C, Siegmund A, Scheunemann P, Schurr P, Knoefel WT, Verde PE, Reichelt U, Erbersdobler A, Grau R, Ullrich A, Izbicki JR, Klein CA: Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell 13:441-53, 2008 |
23,8 |
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| Sienel W, Polzer B, Elshawi K, Lindner M, Morresi-Hauf A, Vay C, Eder F, Passlick B, Klein CA: Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Modern Pathology, 2008 |
4,2 |
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| Husemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, Eils R, Fehm T, Riethmuller G, Klein CA: Systemic spread is an early step in breast cancer. Cancer Cell 13:58-68, 2008 |
23,8 |
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| Fuhrmann C, Schmidt-Kittler O, Stoecklein NH, Petat-Dutter K, Vay C, Bockler K, Reinhardt R, Ragg T, Klein CA: High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res, 2008 |
6,9 |
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| Hartmann CH, Klein CA: Gene expression profiling of single cells on large-scale oligonucleotide arrays. Nucleic Acids Res 34:e143, 2006 |
6,9 |
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| Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle ME, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J: Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441:1011-4, 2006 |
28,7 |
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| Ulmer A, Fischer JR, Schanz S, Sotlar K, Breuninger H, Dietz K, Fierlbeck G, Klein CA: Detection of melanoma cells displaying multiple genomic changes in histopathologically negative sentinel lymph nodes. Clin Cancer Res 11:5425-32, 2005 |
6,3 |
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| Schardt JA, Meyer M, Hartmann CH, Schubert F, Schmidt-Kittler O, Fuhrmann C, Polzer B, Petronio M, Eils R, Klein CA: Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 8:227-39, 2005 |
23,8 |
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Methods
- Molecular-genetic methods
- Genomic methods (microarray)
- Molecular biology
- Animal models
- In-vitro models
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