Publications since 2000

2014

Gerl M, Kurt B, Kurtz A, Wagner C.
Connexin 43 is not essential for the control of renin synthesis and secretion.
Pflugers Arch. 2014 May;466(5):1003-9.
[Pubmed]

Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp JB, Sequeira-Lopez ML, Gomez RA, Hohenstein B, Todorov VT, Hugo CP.
Renin Lineage Cells Repopulate the Glomerular Mesangium after Injury.
J Am Soc Nephrol. 2014 Jun 5. pii: ASN.2014030265.
[Pubmed]

Kurt B, Karger C, Wagner C, Kurtz A.
Control of renin secretion from kidneys with renin cell hyperplasia.
Am J Physiol Renal Physiol. 2014 Feb;306(3):F327-32.
[Pubmed]

2013

Karger C, Kurtz F, Steppan D, Schwarzensteiner I, Machura K, Angel P, Banas B, Risteli J, Kurtz A.
Procollagen I-expressing renin cell precursors.
Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F355-61.
[Pubmed]

Kurtz A.
Pericytes on the move.
Pflugers Arch. 2013 Jun;465(6):765.
[Pubmed]

Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, Sequeira-Lopez ML, Bachmann S, Gomez RA, Eckardt KU, Kurtz A
Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.
J Am Soc Nephrol. 2013 Feb;24(3):433-44. doi: 10.1681/ASN.2012080791. Epub 2013 Feb 7.
[Pubmed]

Neubauer B, Machura K, Rupp V, Tallquist MD, Betsholtz C, Sequeira-Lopez ML, Gomez RA, Wagner C
Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling.
Physiol Rep. 2013 Oct;1(5):e00132. Epub 2013 Oct 24.
[Pubmed]

Machura K, Iankilevitch E, Neubauer B, Theuring F, Kurtz A.
The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.
Am J Physiol Renal Physiol. 2013 Jan 9. [Epub ahead of print]
[Pubmed]

Neubauer B, Machura K, Kettl R, Sequeira Lopez ML, Friebe A, Kurtz A.
Endothelium-Derived Nitric Oxide Supports Renin Cell Recruitment Through the Nitric Oxide-Sensitive Guanylate Cyclase Pathway.
Hypertension. 2013 Jan 7.[Epub ahead of print]
[Pubmed] [read also editorial]

2012

Steppan D, Zügner A, Rachel R, Kurtz A.
Structural analysis suggests that renin is released by compound exocytosis.
Kidney Int. 2012 Dec 12. doi: 10.1038/ki.2012.392.
[Pubmed]

Wagner C, Kurtz A.
Distribution and functional relevance of connexins in renin-producing cells.
Pflugers Arch. 2012 Jun 29.
[Pubmed]

Machura K, Neubauer B, Steppan D, Kettl R, Groβ A, Kurtz A.
Role of blood pressure in mediating the influence of salt intake on renin expression in the kidney.
Am J Physiol Renal Physiol. 2012 May 15;302(10):F1278-85.
[Pubmed]

Kurtz A.
Control of renin synthesis and secretion.
Am J Hypertens. 2012 Aug;25(8):839-47.
[Pubmed]

2011

Schweda F, Kurtz A.
Regulation of renin release by local and systemic factors.
Rev Physiol Biochem Pharmacol. 2011;161:1-44.
[Pubmed]

Höcherl K, Gerl M, Schweda F.
Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release.
Hypertension. 2011 Oct;58(4):611-8. Epub 2011 Aug 22.
[Pubmed]

Lübkemeier I, Machura K, Kurtz L, Neubauer B, Dobrowolski R, Schweda F, Wagner C, Willecke K, Kurtz A.
The Connexin40 A96S Mutation Causes Renin-Dependent Hypertension.
J Am Soc Nephrol. 2011 May 19. [Epub ahead of print]
[Pubmed]

Desch M, Harlander S, Neubauer B, Gerl M, Germain S, Castrop H, Todorov VT.
cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Pflugers Arch. 2011 May;461(5):567-77.
[Pubmed]

Neubauer B, Machura K, Schnermann JB, Wagner C.
Renin expression in large renal vessels during fetal development depends on functional {beta}1/{beta}2-adrenergic receptors.
Am J Physiol Renal Physiol. 2011 Mar 9. [Epub ahead of print]
[Pubmed]

Kurtz A.
Renin release: sites, mechanisms, and control.
Annu Rev Physiol. 2011 Mar 17;73:377-99.
[Pubmed]

Kurt B, Kurtz L, Sequeira-Lopez ML, Gomez RA, Willecke K, Wagner C, Kurtz A.
Reciprocal expression of connexin 40 and 45 during phenotypical changes of renin secreting cells.
Am J Physiol Renal Physiol. 2011 Mar;300(3):F743-8. Epub 2011 Jan 5.
[Pubmed]

2010

Kurtz A.
Salt intake and the nitric oxide-cyclic AMP signaling pathway in renin secreting cells.
Am J Hypertens. 2010 Nov;23(11):1157.
[Pubmed]

Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Lopez ML, Gomez RA, van Veen TA,de Wit C, Kurtz A.
Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.
Kidney Int. 2010 Oct;78(8):762-8.
[Pubmed]

Kurtz L, Madsen K, Kurt B, Jensen BL, Walter S, Banas B, Wagner C, Kurtz A.
High-level connexin expression in the human juxtaglomerular apparatus.
Nephron Physiol. 2010;116(1):p1-8. Epub 2010 Jun 8.
[Pubmed]

Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C.
Physiology of kidney renin.
Physiol Rev. 2010 Apr;90(2):607-73. Review.
[Pubmed]

Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT.
Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Hypertension. 2010 Mar;55(3):660-6.
[Pubmed]

Schmidt C, Höcherl K, Kurt B, Moritz S, Kurtz A, Bucher M.
Blockade of multiple but not single cytokines abrogates downregulation of angiotensin II type-I receptors and anticipates septic shock.
Cytokine. 2010 Jan;49(1):30-8.
[Pubmed]

2009

Machura K, Steppan D, Neubauer B, Alenina N, Coffman TM, Facemire CS, Hilgers KF, Eckardt KU, Wagner C, Kurtz A.
Developmental renin expression in mice with a defective renin-angiotensin system.
Am J Physiol Renal Physiol. 2009 Nov;297(5):F1371-80.
[Pubmed]

Hocherl K, Schmidt C, Kurt B, Bucher M.
Inhibition of NF-{kappa}B ameliorates sepsis-induced downregulation of aquaporin-2 / V2 receptor expression and acute renal failure in vivo.
Am J Physiol Renal Physiol. 2009 Oct 14.
[Pubmed]

Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J.
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Nat Med. 2009 May;15(5):545-52. Epub 2009 May 3.
[Pubmed]

Neubauer B, Machura K, Chen M, Weinstein LS, Oppermann M, Sequeira-Lopez ML, Gomez RA, Schnermann J, Castrop H, Kurtz A, Wagner C.
Development of vascular renin expression in the kidney critically depends on the cyclic AMP pathway.
Am J Physiol Renal Physiol. 2009 May;296(5):F1006-12.
[Pubmed]

Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C.
Connexin expression in Renin-producing cells.
J Am Soc Nephrol. 2009 Mar;20(3):506-12.
[Pubmed]

Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C.
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int. 2009 Mar;75(5):482-9.
[Pubmed] [read also editorial]

Gadau J, Peters H, Kastner C, Kühn H, Nieminen-Kelhä M, Khadzhynov D, Krämer S, Castrop H, Bachmann S, Theilig F.
Mechanisms of tubular volume retention in immune-mediated glomerulonephritis.
Kidney Int. 2009 Feb 4.
[Pubmed]

2008

Schmidt C, Kurt B, Höcherl K, Bucher M.
Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis.
Shock. 2008 Dec 22.
[Pubmed]

Höcherl K, Schmidt C, Bucher M.
COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.
Kidney Int. 2008 Oct 22.
[Pubmed]

Höcherl K, Schmidt C, Kurt B, Bucher M.
Activation of the PGI2/IP System Contributes to the Development of Circulatory Failure in a Rat Model of Endotoxic Shock.
Hypertension. 2008 Jul 7.
[Pubmed]

Schmidt C, Höcherl K, Kurt B, Bucher M.
Role of NF-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure.
Crit Care Med. 2008 Jul 1.
[Pubmed]

Todorov VT, Desch M, Schubert T, Kurtz A.
The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by PPAR{gamma}.
Endocrinology. 2008 May 15.
[Pubmed]

Wagner C.
Function of connexins in the renal circulation.
Kidney Int. 2008 Mar;73(5):547-55.
[Pubmed]

Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann JB.
Tubuloglomerular Feedback and Renin Secretion in NTPDase1/CD39-Deficient Mice.
Am J Physiol Renal Physiol. 2008 Feb 6.
[Pubmed]

2007

Kurtz A, Eckardt KU.
Hematopoiesis and the kidney.
The Kidney (eds. Alpern RJ and Hebert SC), Elsevier, 2008, pp 2681-2718.

Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K.
Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys.
Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1781-6. Epub 2007 Sep 12.
[Pubmed]

Hayo Castrop, Mona Oppermann, Diane Mizel, Yuning Huang, Robert Faulhaber-Walter, Yvonne Weiss, Lee S. Weinstein, Min Chen, Stephane Germain, Huiyan Lu, Dan Ragland, Daniel M. Schimel, Jurgen Schnermann.
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsα deletion caused by a renin promoter-Cre transgene.
Cell Tissue Res. 2007 (in press).

Schweda F, Friis U, Wagner C, Skott O, Kurtz A.
Renin release.
Physiology (Bethesda). 2007 Oct;22:310-9.
[Pubmed]

Todorov VT, Desch M, Schmitt-Nilson N, Todorova A, Kurtz A.
Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.
Hypertension. 2007 Nov;50(5):939-44. Epub 2007 Sep 4.
[Pubmed] [read also editorial]

Schmidt C, Höcherl K, Schweda F, Bucher M.
Proinflammatory cytokines cause downregulation of renal chloride entry pathways during sepsis.
Crit Care Med. 2007, 35(9): 2110-2119.
[Pubmed] [read also editorial]

Matzdorf C, Kurtz A, Höcherl K.
COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys.
Am J Physiol Renal Physiol. 2007; 292:F1782-1790.
[Pubmed]

Schmidt C, Höcherl K, Bucher M.
Cytokine-mediated regulation of urea transporters during experimental endotoxemia.
Am J Physiol Renal Physiol. 2007; 292:F1479-1489.
[Pubmed]

Schmidt C, Höcherl K, Schweda F, Kurtz A, Bucher M.
Regulation of renal sodium transporters during severe inflammation.
J Am Soc Nephrol. 2007; 18:1072-1083.
[Pubmed]

Schmidt C, Höcherl K, Bucher M.
Regulation of renal glucose transporters during severe inflammation.
Am J Physiol Renal Physiol. 2007; 292:F804-811.
[Pubmed]

Sauter A, Machura K, Neubauer B, Kurtz A, Wagner C.
Development of renin expression in the mouse kidney.
Kidney Int. 2007 Sep 26; [Epub ahead of print], doi:10.1038/sj.ki.5002571.
[Pubmed]

Wagner C.
Function of connexins in the renal circulation.
submitted to Kidney Int.

Wagner C, de Wit C, Kurtz A, Höcherl K.
Increased expression of cyclooxygenase 2 contributes to abberrant renin production in connexin 40 deficient kidneys.
submitted to Am J Physiol Renal Physiol.

Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F.
Connexin 40 is essential for the pressure control of renin synthesis and secretion.
Circ Res 2007; 100 (4): 556-563.
[Pubmed] [read also editorial]

Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Saueter A, Kurtz A, Wagner C.
Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol 2007; 18: 1103-1111.
[Pubmed] [read also editorial]

2006

Kurtz A, Schweda F.
Osmolarity-induced renin secretion from kidneys: evidence for readily releasable renin pools.
Am J Physiol Renal Physiol. 2006 Apr;290(4):F797-805. Epub 2005 Oct 25.
[Pubmed] [read also editorial]

Lotter K, Höcherl K, Bucher M, Kees F.
In vivo efficacy of telithromycin on cytokine and nitric oxide formation in lipopolysaccharide-induced acute systemic inflammation in mice.
J Antimicrob Chemother. 2006; 58:615-621.
[Pubmed]

2005

Höcherl K, Hensel C, Ulbricht B, Krämer BK.
Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidney.
Br J Pharmacol. 2005; 145:1112-1122.
[Pubmed]

Nuesing, R.E., A. Treude, C. Weissenberger, B. Jensen, M. Bek, C. Wagner, S. Narumiya, H.W. Seyberth.
Dominant role of prostaglandin E2 EP4-receptor in furosemide-induced salt losing tubulopathy, a model for the hyperprostaglandin E syndrome/antenatal Bartter syndrome.
J. Am. Soc. Nephrol. 16(8)(2005).
[Pubmed]

Schumacher K, Klar J, Wagner C, Minuth WW.
Temporal-spatial co-localisation of tissue transglutaminase (Tgase2) and matrix metalloproteinase-9 (MMP-9) with SBA-positive micro-fibres in the embryonic kidney cortex.
Cell Tissue Res. 319(3):491-500 (2005).
[Pubmed]

2004

Höcherl K, Kees F, Krämer BK, Kurtz A.
Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression.
Kidney Int. 2004; 65:2071-2080.
[Pubmed]

Schweda F, Kammerl M, Wagner C, Kramer BK, Kurtz A.
Upregulation of macula densa cyclooxygenase-2 expression is not dependent on glomerular filtration.
Am J Physiol Renal Physiol 2004; 287(1): F95-101.
[Pubmed]

Richter CM; Godes M, Wagner C, Maser-Gluth C, Herzfeld S, Dorn M, Priem F, Slowinski T, Bauer C, Schneider W, Neumayer HH, Kurtz A, Hocher B.
Chronic cyclooxygenase-2 inhibition does not alter blood pressure and kidney function in renovascular hypertensive rats.
J Hypertens 2004; 22(1):191-198.
[Pubmed]

2003

Castrop H, Klar J, Wagner C, Höcherl K, Kurtz A.
General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system.
Am J Physiol Renal Physiol. 2003; 284:F518-524.
[Pubmed]

Wagner C, Vitzthum H, Castrop H, Schumacher K, Bucher M, Albertin S, Coffman TM, Arendshorst WJ, Kurtz A.
Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
Am J Physiol Renal Physiol. 2003; 284:F518-524.
[Pubmed]

Schweda F, Wagner C, Kramer BK, Schnermann J, Kurtz A.
Preserved macula densa dependent renin secretion in A1 adenosine receptor knockout mice.
Am J Physiol Renal Physiol 2003; 284(4): F770-777.
[Pubmed]

2002

Höcherl K, Dreher F, Kurtz A, Bucher M.
Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure.
Hypertension. 2002; 40:947-953.
[Pubmed]

Höcherl K, Dreher F, Vitzthum H, Köhler J, Kurtz A.
Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidney.
J Am Soc Nephrol. 2002; 13:2427-2436.
[Pubmed]

Höcherl K, Endemann D, Kammerl MC, Grobecker HF, Kurtz A.
Cyclo-oxygenase-2 inhibition increases blood pressure in rats.
Br J Pharmacol. 2002; 136:1117-1126.
[Pubmed]

Höcherl K, Kammerl MC, Schuhmcher K, Endemann D, Grobecker HF, Kurtz A.
Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake.
Am J Physiol Renal Physiol. 2002; 283:F294-301.
[Pubmed]

Höcherl K, Kammerl M, Kees F, Krämer BK, Grobecker HF, Kurtz A.
Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency.
Am J Physiol Renal Physiol. 2002; 282:F478-484.
[Pubmed]

2001

Höcherl K, Wolf K, Castrop H, Ittner KP, Bucher M, Kees F, Grobecker HF, Kurtz A.
Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linked.
Pflügers Arch. 2001; 442:821-827.
[Pubmed]

Wolf K, Kurtz A, Pfeiffer M, Höcherl K, Riegger GA, Krämer BK.
Different regulation of left ventricular ANP, BNP and adrenomedullin mRNA in the two-kidney, one-clip model of renovascular hypertension.
Pflügers Arch. 2001; 442:212-217.
[Pubmed]

Mann B, Hartner A, Jensen BL, Hilgers KF, Höcherl K, Krämer BK, Kurtz A.
Acute upregulation of COX-2 by renal artery stenosis.
Am J Physiol Renal Physiol. 2001; 280:F119-125.
[Pubmed]

2000

Höcherl K, Färber L, Ladenburger S, Vosshage D, Stratz T, Müller W, Grobecker H.
Effect of tropisetron on circulating catecholamines and other putative biochemical markers in serum of patients with fibromyalgia.
Scand J Rheumatol Suppl. 2000; 113:46-48.
[Pubmed]

Wagner, C., Godecke, A., Ford, M., Schnermann, J., Schrader, J., Kurtz, A.
Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.
Eur J Physiol. 439(5), 567-72.
[Pubmed]

Todorov V, Gess B, Gödecke A, Wagner C, Schräder J, Kurtz A.
Endogenous nitric oxide attenuates erythropoietin gene expression in vivo.
Pflugers Arch. 2000 Feb;439(4):445-8.
[Pubmed]