Publikationen seit 2000


Castrop H, Schießl IM.
Novel routes of albumin passage across the glomerular filtration barrier.
Acta Physiol (Oxf). 2016 Jul 25. doi: 10.1111/apha.12760. [Epub ahead of print] Review.

Grill A, Schießl IM, Gess B, Fremter K, Hammer A, Castrop H.
Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene.
Acta Physiol (Oxf). 2016 Jul 16. doi: 10.1111/apha.12755. [Epub ahead of print]

Schießl IM, Castrop H.
Deep insights: intravital imaging with two-photon microscopy.
Pflugers Arch. 2016 Sep;468(9):1505-16. doi: 10.1007/s00424-016-1832-7. Epub 2016 Jun 28. Review.

Schießl IM, Hammer A, Riquier-Brison A, Peti-Peterdi J.
Just Look! Intravital Microscopy as the Best Means to Study Kidney Cell Death Dynamics.
Semin Nephrol. 2016 May;36(3):220-36. doi: 10.1016/j.semnephrol.2016.03.009. Review.

Otaño-Rivera V, Boakye A, Grobe N, Almutairi MM, Kursan S, Mattis LK, Castrop H, Gurley SB, Elased KM, Boivin GP, Di Fulvio M.
A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots.
Lab Anim. 2016 May 9. pii: 0023677216646088. [Epub ahead of print]

Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach KJ, Grill A, Kockskämper J, Castrop H.
The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a.
Cardiovasc Res. 2016 Jun 1;110(3):359-70. doi: 10.1093/cvr/cvw064. Epub 2016 Mar 25.


Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J.
Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration.
FEBS J. 2015 Oct;282(19):3786-98. doi: 10.1111/febs.13376. Epub 2015 Jul 30.

Schießl IM, Castrop H.
Regulation of NKCC2 splicing and phosphorylation.
Curr Opin Nephrol Hypertens. 2015 Sep;24(5):457-62. doi: 10.1097/MNH.0000000000000150. Review.

Schießl IM, Hammer A, Kattler V, Gess B, Theilig F, Witzgall R, Castrop H.
Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.
J Am Soc Nephrol. 2016 Mar;27(3):731-44. doi: 10.1681/ASN.2014111125. Epub 2015 Jun 26.

Mederle K, Meurer M, Castrop H, Höcherl K.
Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice.
Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F332-40. doi: 10.1152/ajprenal.00567.2014. Epub 2015 May 27.

Schießl IM, Kattler V, Castrop H.
In vivo visualization of the antialbuminuric effects of the angiotensin-converting enzyme inhibitor enalapril.
J Pharmacol Exp Ther. 2015 May;353(2):299-306. doi: 10.1124/jpet.114.222125. Epub 2015 Feb 13.

Castrop H.
A role for AT1 receptor-associated proteins in blood pressure regulation.
Curr Opin Pharmacol. 2015 Apr;21:43-7. doi: 10.1016/j.coph.2014.12.009. Epub 2015 Jan 3. Review.


Castrop H.
Reply to "Letter to the editor: 'Quantifying albumin permeability with multiphoton microscopy: why the difference?'".
Am J Physiol Renal Physiol. 2014 May 1;306(9):F1101-3. doi: 10.1152/ajprenal.00038.2014.

Edwards A, Castrop H, Laghmani K, Vallon V, Layton AT.
Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study.
Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F137-46. doi: 10.1152/ajprenal.00158.2014. Epub 2014 May 21.

Castrop H.
Blunted renal autoregulation during high salt intake: advantageous or deleterious?
Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F273-4. doi: 10.1152/ajprenal.00293.2014. Epub 2014 Jun 4. No abstract available.

Castrop H, Schießl IM.
Physiology and Pathophysiology of the Renal Na/K/2Cl Cotransporter NKCC2.
Am J Physiol Renal Physiol. 2014 Sep 3. pii: ajprenal.00432.2014. Epub 2014 Sep 3. Review


Castrop H.
Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system.
Pflugers Arch. 2013 Jan;465(1):111-9. Epub 2012 May 16. Review.

Schießl IM, Bardehle S, Castrop H.
Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney.
PLoS One. 2013;8(1):e52499. Epub 2013 Jan 21.

Castrop H, Kurtz A, Schweda F.
A special issue on the renin-angiotensin system.
Pflugers Arch. 2013 Jan;465(1):1. No abstract available.

Mederle K, Mutig K, Paliege A, Carota I, Bachmann S, Castrop H, Oppermann M.
Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse.
Am J Physiol Renal Physiol. 2013 May 1;304(9):F1198-209. Epub 2013 Feb 20.

Oppermann M, Carota I, Schiessl I, Eisner C, Castrop H, Schnermann J.
Direct assessment of tubuloglomerular feedback responsiveness in connexin 40-deficient mice.
Am J Physiol Renal Physiol. 2013 May 1;304(9):F1181-6. Epub 2013 Feb 27.

Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Höcherl K, Oike Y, Castrop H.
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
Crit Care. 2013 Jul 11;17(4):R130. [Epub ahead of print]

Schießl IM, Castrop H.
Angiotensin II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin - a multiphoton microscopy study.
Am J Physiol Renal Physiol. 2013 Aug 14. [Epub ahead of print]

Schießl IM, Rosenauer A, Kattler V, Minuth WW, Oppermann M, Castrop H.
Dietary Salt Intake Modulates Differential Splicing of the Na/K/2Cl Cotransporter NKCC2.
Am J Physiol Renal Physiol. 2013 Aug 28. [Epub ahead of print]


Doblinger E, Höcherl K, Mederle K, Kattler V, Walter S, Hansen PB, Jensen B, Castrop H.
Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.
Am J Physiol Renal Physiol. 2012 May 15;302(10):F1313-24. Epub 2012 Feb 22.

Barro-Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, Strauß O.
Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
PLoS One. 2012;7(11):e49624. Epub 2012 Nov 20.


Desch M, Harlander S, Neubauer B, Gerl M, Germain S, Castrop H, Todorov VT.
cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Pflugers Arch. 2011 May;461(5):567-77.


Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C.
Physiology of kidney renin.
Physiol Rev. 2010, 90(2):607-73.

Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F.
Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
J Biol Chem. 2010. epub

Carota I, Theilig F, Oppermann M, Kongsuphol P, Rosenauer A, Schreiber R, Jensen BL, Walter S, Kunzelmann K, Castrop H.
Localization and Functional Characterization of the Human NKCC2 Isoforms.
Acta Physiol (Oxf). 2010 Feb 8. [Epub ahead of print]

Castrop H.
Genetically modified mice-successes and failures of a widely used technology.
Pflugers Arch. 2010 Mar;459(4):557-67. Epub 2010 Feb 6.

Castrop H, Kurtz A.
Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex.
Kidney Int. 2010 Feb;77(4):269-71.

Oppermann M, Gess B, Schweda F, Castrop H.
Atrap deficiency increases arterial blood pressure and plasma volume.
J Am Soc Nephrol. 2010 Mar;21(3):468-77. Epub 2010 Jan 21.


Oppermann M, Qin Y, Lai EY, Eisner C, Li L, Huang YG, Mizel D, Fryc J, Wilcox CS, Briggs JP, Schnermann JB, Castrop H.
Enhanced Tubuloglomerular Feedback (TGF) in Mice with Vascular Over-Expression of A1 Adenosine Receptors (A1AR).
Am J Physiol Renal Physiol. 2009 Sep 9.

Ostreicher I, Meißner U, Plank C, Allabauer I, Castrop H, Rascher W, Dötsch J.
Altered leptin secretion in hyperinsulinemic mice under hypoxic conditions.
Regul Pept. 2009 Feb 25;153(1-3):25-29.

Gadau J, Peters H, Kastner C, Kühn H, Nieminen-Kelhä M, Khadzhynov D, Krämer S, Castrop H, Bachmann S, Theilig F.
Mechanisms of tubular volume retention in immune-mediated glomerulonephritis.
Kidney Int. 2009 Apr;75(7):699-710.


Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J.
Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice.
Am J Physiol Renal Physiol. 2008 Apr;294(4):F965-70.

Blattmann A, Denk L, Strehl R, Castrop H, Minuth WW.
The formation of pores in the basal lamina of regenerated renal tubules.
Biomaterials. 2008 Jun;29(18):2749-56.

Minuth WW, Denk L, Castrop H.
Generation of tubular superstructures by piling of renal stem/progenitor cells.
Tissue Eng Part C Methods. 2008 Mar;14(1):3-13.

Castrop H.
Modulation of adenosine receptor expression in the proximal tubule: a novel adaptive mechanism to regulate renal salt and water metabolism.
Am J Physiol Renal Physiol. 2008 Jul;295(1):F35-6.

Castrop H, Schnermann J.
Isoforms of renal Na-K-2Cl cotransporter NKCC2: expression and functional significance.
Am J Physiol Renal Physiol. 2008 Oct;295(4):F859-66.

Schreiber R, Castrop H, Kunzelmann K.
Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice.
Pflugers Arch. 2008 Nov;457(2):431-40.

Allen AM, O'Callaghan EL, Hazelwood L, Germain S, Castrop H, Schnermann J, Bassi JK.
Distribution of cells expressing human renin-promoter activity in the brain of a transgenic mouse.
Brain Res. 2008 Dec 3;1243:78-85.

Jacob VA, Harbaugh CM, Dietz JR, Fenton RA, Kim SM, Castrop H, Schnermann J, Knepper MA, Chou CL, Anderson SA.
Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities.
Kidney Int. 2008 Nov;74(9):1202-8.


Oppermann M, Mizel D, Kim SM, Chen L, Faulhaber-Walter R, Huang Y, Li C, Deng C, Briggs J, Schnermann J, Castrop H.
Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter.
J Am Soc Nephrol. 2007 Feb;18(2):440-8.

Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schütz G, Schweda F.
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
J Am Soc Nephrol. 2007 Apr;18(4):1150-6.

Oppermann M, Hansen PB, Castrop H, Schnermann J.
Vasodilatation of afferent arterioles and paradoxical increase of renal vascular resistance by furosemide in mice.
Am J Physiol Renal Physiol. 2007 Jul;293(1):F279-87.

Castrop H, Oppermann M, Mizel D, Huang Y, Faulhaber-Walter R, Weiss Y, Weinstein LS, Chen M, Germain S, Lu H, Ragland D, Schimel DM, Schnermann J.
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene.
Cell Tissue Res. 2007 Dec;330(3):487-501.

Castrop H.
Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine.
Acta Physiol (Oxf). 2007 Jan;189(1):3-14.


Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J.
Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene.
Physiol Genomics. 2006 Apr 13;25(2):277-85.

Oppermann M, Mizel D, Huang G, Li C, Deng C, Theilig F, Bachmann S, Briggs J, Schnermann J, Castrop H.
Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter.
J Am Soc Nephrol. 2006 Aug;17(8):2143-52.


Castrop H, Lorenz JN, Hansen PB, Friis U, Mizel D, Oppermann M, Jensen BL, Briggs J, Skøtt O, Schnermann J.
Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretion.
Am J Physiol Renal Physiol. 2005 Dec;289(6):F1185-92.

Schweda F, Segerer F, Castrop H, Schnermann J, Kurtz A.
Blood pressure-dependent inhibition of Renin secretion requires A1 adenosine receptors.
Hypertension. 2005 Oct;46(4):780-6.


Castrop H, Schweda F, Mizel D, Huang Y, Briggs J, Kurtz A, Schnermann J.
Permissive role of nitric oxide in macula densa control of renin secretion.
Am J Physiol Renal Physiol. 2004 May;286(5):F848-57.

Hashimoto S, Huang YG, Castrop H, Hansen PB, Mizel D, Briggs J, Schnermann J.
Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice.
Pflugers Arch. 2004 Sep;448(6):621-8.

Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F, Bachmann S, Deng C, Briggs J, Schnermann J.
Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice.
J Clin Invest. 2004 Sep;114(5):634-42.


Castrop H, Klar J, Wagner C, Hocherl K, Kurtz A.
General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system.
Am J Physiol Renal Physiol. 2003 Mar;284(3):F518-24.

Wolf K, Meier-Meitinger M, Bergler T, Castrop H, Vitzthum H, Riegger GA, Kurtz A, Krämer BK.
Parallel down-regulation of chloride channel CLC-K1 and barttin mRNA in the thin ascending limb of the rat nephron by furosemide.
Pflugers Arch. 2003 Sep;446(6):665-71.

Wagner C, Vitzthum H, Castrop H, Schumacher K, Bucher M, Albertin S, Coffman TM, Arendshorst WJ, Kurtz A.
Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
Pflugers Arch. 2003 Nov;447(2):214-22.

Hansen PB, Castrop H, Briggs J, Schnermann J.
Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice.
J Am Soc Nephrol. 2003 Oct;14(10):2457-65.


Vitzthum H, Castrop H, Meier-Meitinger M, Riegger GA, Kurtz A, Krämer BK, Wolf K.
Nephron specific regulation of chloride channel CLC-K2 mRNA in the rat.
Kidney Int. 2002 Feb;61(2):547-54.

Castrop H, Vitzthum H, Schumacher K, Schweda F, Kurtz A.
Low tonicity mediates a downregulation of cyclooxygenase-1 expression by furosemide in the rat renal papilla.
J Am Soc Nephrol. 2002 May;13(5):1136-44.

Schumacher K, Castrop H, Strehl R, de Vries U, Minuth WW.
Cyclooxygenases in the collecting duct of neonatal rabbit kidney.
Cell Physiol Biochem. 2002;12(2-3):63-74.

Yang T, Forrest SJ, Stine N, Endo Y, Pasumarthy A, Castrop H, Aller S, Forrest JN Jr, Schnermann J, Briggs J.
Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion.
Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R631-7.


Castrop H, Schweda F, Schumacher K, Wolf K, Kurtz A.
Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion.
J Am Soc Nephrol. 2001 May;12(5):867-74.

Castrop H, Kurtz A.
Differential nNOS gene expression in salt-sensitive and salt-resistant Dahl rats.
J Hypertens. 2001 Jul;19(7):1223-31.

Wolf K, Castrop H, Riegger GA, Kurtz A, Krämer BK.
Differential gene regulation of renal salt entry pathways by salt load in the distal nephron of the rat.
Pflugers Arch. 2001 Jul;442(4):498-504.

Höcherl K, Wolf K, Castrop H, Ittner KP, Bucher M, Kees F, Grobecker HF, Kurtz A.
Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linked.
Pflugers Arch. 2001 Sep;442(6):821-7.


Castrop H, Krämer BK, Riegger GA, Kurtz A, Wolf K.
Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats.
J Hypertens. 2000 Sep;18(9):1289-95.

Castrop H, Kammerl M, Mann B, Jensen BL, Krämer BK, Kurtz A.
Cyclooxygenase 2 and neuronal nitric oxide synthase expression in the renal cortex are not interdependent in states of salt deficiency.
Pflugers Arch. 2000 Dec;441(2-3):235-40.