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[1] Membrane suspended nanocompartments as a new artificial membrane system for studying light-activated proton pumps and channels
[2] Generation of flavoproteins with modified chromophores in vivo
[3] Role of the compound eyes and extraretinal photoreceptors in synchronizing the activity rhythm of Drosophila melanogaster to light-dark (LD) cycles.
[4] Biochemical studies on FAD derivates
[5] In vitro characterisation of "Channelopsins" from Chlamydomonas reinhardtii
[6] Photophysical and Photochemical Studies on Open-Chain Tetrapyrrole Complexes
[7] Investigation of the photocycle of a plant photoreceptor by Quantum Chemical Calculations and Molecular Dynamics Simulations
For detailed information about announced projects hit one of the links belowchoose number: [1] [2] [3] [4] [5] [6] [7]
project number [7] Investigation of the photocycle of a plant photoreceptor by Quantum Chemical Calculations and Molecular Dynamics Simulations
Two years ago the graduate college “Sensory Photoreceptors” started an investigation of the photocycle
of the Phot1 protein of the green alga Chlamydomonas reinhardtii. The wild type and several
mutants of the first LOV (light oxygen voltage sensitive) domain of this protein were studied
with transient spectroscopy [1,2]. The interpretation of these spectroscopic data so far was
based on calculations of the geometrical and electronic structure of intermediates [3,4].
We plan to extend these theoretical studies to the calculation of the reaction pathways
connecting the intermediates. The influence of the protein environment on the spectra,
the stability of conformers, and the reactivity of the intermediates is another important aspect.
This project is a challenge for a young scientist who likes to work in a highly interdisciplinary
team of biologists, chemists, and spectroscopists. The project will be financed by
the Deutsche Forschungsgemeinschaft by a PhD fellowship. Applicants should have a degree
that permits access to a PhD program in German universities (Dipl. Chem, Dipl. Phys., M Sc, etc.).
Please apply to Prof. Dr. B. Dick,
Lehrstuhl für Physikalische Chemie,
Institut für Physikali-sche und Theoretische Chemie,
93040 Regensburg
Publications:
1. Kottke, T., Heberle, J., Hehn, D., Dick,B., and Hegemann, P. Phot LOV1: Photocycle of a Blue Light Receptor Domain from the Green Alga Chlamydomonas reinhardtii, (2003) Biophys. J. 84, 1192-1201
2. Holzer W., A. Penzkofer A., Fuhrmann M., and Hegemann P. Spectroscopic Characterisation of Flavin Mononucleotide bound to the LOV1 Domain of Chlamydomonas Phot1-receptor, (2002) Photochem. Photobiol.
3. Christian Neiß, Peter Saalfrank Ab Initio Quantum Chemical Investigation of the First Steps of the Photocycle of Phototropin: A Model Study; 2003) Photochem. Photobiol. 2003, 77(1), 101-109
4. Christian Neiß, Peter Saalfrank, Maja Parac, Stefan Grimme Quantum Chemical Calculation of Excited States of Flavin-Related Molecules(2003) J. Phys. Chem. A 2003, 107, 140-147
how to apply ... (in general)
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