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Selected Publications

  • Ettlinger, C. and Lehle, L. (1988) Auxin induces rapid changes in phosphatidylinositol metabolites. Nature 331, 176 - 178.
  • Te Heesen, S., Janetzky, B., Lehle, L. and Aebi,M. (1992) The yeast WBP1 is essential for N-oligosaccharyltransferase in vivo and in vivo. EMBO J. 11, 2071-2075.
  • Te Heesen S., Knauer, R., Lehle.L. and Aebi, M. (1993) Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyltransferase activity. EMBO J. 12, 279-284.
  • Rohrmeier, T. and Lehle.L. (1993) WIP1, a wound inducible gene from maize with homology to Bowman-Birk proteinase inhibitors. Plant Mol. Biol. 22, 783-792.
  • Knauer, R. and Lehle, L. (1994) The N-oligosaccharyltransferase complex from yeast. FEBS Letters 344, 83-86.
  • Knauer, R., Lehle, L. Hanefeld, F. and von Figura, K. (1994) Normal N-oligosaccharyl transferase activity in fibroblasts from patients with carbohydrate-deficient glycoprotein syndrome. J. Inher. Metab. Dis. 17, 541 - 544.
  • Lehle, L., Eiden, A., Lehnert, K., Haselbeck,T. and Kopetzki, E. (1995) Glycoprotein biosynthesis in yeast: ngd29, a yeast mutant allelic to och1 having a defect in outer chain formation. FEBS Letters 370, 41-45.
  • Zufferey, R., Knauer, R., Burda, P., Stagljar, I., TeHeesen, S., Lehle, L and Aebi, M. (1995) STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo. EMBO J. 14, 4949-4960.
  • Körner, C., Lehle, L. and von Figura, K. (1998) Abnormal synthesis of mannose 1-phosphate derived carbohydrates in carbohydrate-deficient glycoprotein syndrome type I fibroblasts with phosphomannomutase deficieny. Glycobiology, 8, 165-172.
  • Rothe, C. and Lehle, L. (1998): Sorting of invertase signal peptide mutants in yeast dependent and independent on the signal-recognition particle. Eur. J. Biochem. 252, 16-24.
  • Körner, C., Knauer*, Lehle,.L. and von Figura, K. (1998) Carbohydrate deficient glycoprotein syndrome type V: deficiency of Dol-P-Glc: Man9GlcNAc2-PP-Dol glucosyltransferase. Proc. Natl. Acad. Sci. USA. 95, 13200-13205. *The first two authors contributed equally to this study.

    Reviews:

  • Lehle, L., (1991) Phosphatidyl inositol metabolism and its role in signal transduction in growing plants. Plant Mol. Biol. 15, 647 - 658.
  • Lehle, L. and Tanner, W. (1995) Protein glycosylation in yeast. In: Montreuil, J. Schachter, H. and Vliegenthart, J.F.G. (Eds.) Glycoproteins, New Comprehensive Biochemistry, Vol. 29a, pp 475-509, Elsevier Science
  • Knauer, R. and Lehle, L. (1999) The oligosaccharyltransferase complex from yeast. Biochim. Biophys. Acta. 1426, 259-273