Publikationsliste Prof. Dr. Dr. Hans Robert Kalbitzer  

Aktuelle Publikationen des Lehrstuhls

Schummel, P., Haag, A., Kremer, W., Kalbitzer, H. R., Winter, R. Cosolvent and Crowding Effects on the Temperature and Pressure Dependent Conformational Dynamics and Stability of Globular Actin. J. Phys. Chem . B , in press. 2016
Godoi, P. H. C., Wilkie-Grantham, R. P., Hishiki, A., Sano, R., Matsuzawa, Y., Yanagi, H., Munte, C. E., Chen, Y., Yao, Y., Marassi, F. M., Kalbitzer, H. R., Matsuzawa, S.-I., and Reed, J. C. Orphan Nuclear Receptor NR4A1 binds a novel protein interaction site on anti-apoptotic B-cell lymphoma gene-2 family proteins. J. Biol. Chem., doi: 10.1074. 2016
De Sanctis, S., Wenzler, M., Kröger, N., Malloni, W. M., Sumper, M., Deutzmann, R., Zadravec, P., Brunner, E., Kremer, W., Kalbitzer, H. R. PSCD domains of pleuralin-1 from the diatom Cylindrotheca fusiformis : NMR-structures and interactions with other biosilica-associated proteins. Structure , in press. 2016
Puthenpurackal Narayanan, S. , Gopalakrishnan Nair, D., Schaal, D., Aguiar, M. B., Wenzel, S., Kremer., W., Schwarzinger, S., Kalbitzer, H. R. Structural transitions in full-length human prion protein detected by xenon as probe and spin labelling of the N-terminal domain. Scientific Reports , in press. 2016
Frach, R., Kibies, P., Böttcher, S., Pongratz, T., Strohfeldt, S., Kurrmann, S., Koehler, J., Hofmann, M., Kremer, W., Kalbitzer, H. R. , Reiser, O., Horinek, D., Kast, S. M. The Chemical Shift Baseline for High-Pressure NMR Spectroscopy of Proteins. Angew. Chemie , in press. 2016
Beck Erlach, M., Kalbitzer H. R. , Winter, R., Kremer, W. Conformational Substates of Amyloidogenic hIAPP Revealed by High Pressure NMR Spectroscopy. ChemSelect , in press. 2016
Beck Erlach, M., Koehler, J., Crusca, E. Jr., Kremer, W., Munte, C. E., Kalbitzer, H. R. Pressure Dependence of Backbone Chemical Shifts in the Model Peptides Ac-Gly-Gly-Xxx-Ala-NH2. J. Biomol. NMR, in press. 2016


Kalbitzer, H. R. High Pressure NMR Methods for Characterizing Functional Substates of Proteins. In “ High Pressure Bioscience - Basic Concepts, Applications and Frontiers ” ( K. Akasaka and H. Matsuki, eds, pp. 179-198), Springer, Heidelberg, Germany. 2015


Kalbitzer, H. R. Kap. 5 Proteine – Struktur und Funktion. In: „Biochemie und Pathobiochemie“ (P. C. Heinrich, M. Müller, L. Graeve, eds), pp. 61 to 85, 9 th edition, Springer Verlag, Heidelberg. 2014
Kalbitzer, H. R. Kap. 6 Proteine – Analytische Untersuchungsmethoden, Synthese und Isolierung Proteine. Biochemie und Pathobiochemie“ (P. C. Heinrich, M. Müller, L. Graeve, eds), pp. 86 to 100, 9 th edition, Springer Verlag, Heidelberg. 2014
Mücke, K., Paulus, C., Bernhardt, K., Gerrer, K., Schön, K., Fink, A., Sauer, E.-M., Asbach-Nitzsche, A., Harwardt, T., Kieninger, B., Kremer, W., Kalbitzer, H. R. and Nevels, M. Human Cytomegalovirus Major Immediate-Early 1 Protein Targets Host Chromosomes by Docking to the Acidic Pocket on the Nucleosome Surface J. Virol. 88 , 1228-1248. 2014
Beck Erlach, M., Koehler, J., Moeser , B., Horinek, D., Kremer, W., and Kalbitzer, H. R. Relationship between non-linear pressure induced chemical shift changes and thermodynamic parameters. J. Chem. Phys. B 18 , 5681-5690. 2014
Rosnizeck, I. C., Filchtinski , D., Lopes, R. P., Kieninger, B., Herrmann, C., Kalbitzer, H. R. and Spoerner, M. Elucidating the mode of action of a typical Ras state 1(T) inhibitor. Biochemistry 53 , 3867-3878. 2014
Koehler, J., Beck Erlach, M. Crusca, E. Jr,, Kremer, W., Munte, C. E., Meier, A. and Kalbitzer, H. R. Pressure response of amide one-bond J -couplings in model peptides and proteins. J. Biomol. NMR 60 , 45-50. 2014
Herrnberger, L., Hennig, R., Kremer, W., Hellerbrand, C., Goepferich, A., Kalbitzer, H. R. , Tamm, E. R.

Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage.

PLoS ONE 9 (11), 1-26: e115005. doi:10.1371. 2014
! Miertzschke, M., Koerner, C., Spoerner, M. & Wittinghofer, A. Structural insights into the small G protein Arl13B and implications for Joubert Syndrome. Biochem. J. 457, 301-311. 2014
!Zeraik, A.E., Pereira, H.M., Santos, Y.V., Brandão-Neto, J., Spoerner, M., Santos, M.S., Colnago, L.A., Garratt, R.C., Araújo, A.P.U., DeMarco, R. Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide. J. Biol. Chem. 289 : 7799-7811. 2014


Munte, C, E., Beck Erlach, M., Kremer, W., Koehler, J., and Kalbitzer, H. R.

Getrennte Konformationszustände des Alzheimer- b -Amyloidpeptids – Nachweis mit Hochdruck-NMR-Spektroskopie.

Angew. Chem . 125 , 9111 –9116 2013

Kalbitzer, H. R., Spoerner, M.

State 1(T) Inhibitors of Activated Ras. In The Enzymes, Vol. 33, pp. 69-94, F. Tamanoi (ed.), Academic Press, Burlington. 2013
Jank, T., Bogdanovic, X., Wirth, C., Haaf, E., Spoerner, M., Böhmer, K., E., Steinemann, M., Orth, J. H. C., Kalbitzer, H. R ., Warscheid, B., Hunte, C. & Aktories, K. A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nature Struct. Mol. Biol., 20, 1273-1280. 2013
Kremer, W., Weyand, M., Winklmeier, A., Schreier, C., and Kalbitzer, H. R. 1.2 A X-ray structure of the renal potassium channel K v 1.3 T1 domain. Prot. J . 32, 533–542. 2013

Kalbitzer, H. R. , Rosnizeck, I. C., Munte, C. E., Puthenpurackal Narayanan, S., Kropf, V., and Spoerner, M.

Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High Pressure NMR Spectroscopy. Chem. 125, 14492 –14496. 2013
Kalbitzer, H. R., Kremer, W., Spoerner, M., and Sander, P. NMR-Spektroskopie – Strukturanalytik von Biomolekülen in atomarer Auflösung. Blick in die Wissenschaft 27 , 13-17. 2013
Munte, C, E., Beck Erlach, M., Kremer, W., Koehler, J., and Kalbitzer, H. R. Distinct Conformational States of the Alzheimer b -Amyloid Peptide can be Detected by High Pressure NMR Spectroscopy. Angew. Chem . 125 , 9111 –9116 ; Angew. Chem. Int. Ed. 52 , 8943 –8947. 2013
Sander, P. R., Hau, P., Koch, S., Schütze, K., Bogdahn, U., Kalbitzer, H. R. and Aigner, L. Stem Cell Metabolic and Spectroscopic Profiling. Trends Biotechnol ., 31 , 204-213. 2013
Sander, P., Peer, M., Grandl, M., Bogdahn, U., Schmitz, G., and Kalbitzer, H. R . NMR Spectroscopy of Macrophages Loaded with Native, Oxidized or Enzymatically Degraded Lipoproteins. PLoS One 8 (2), 1-9, e56360.doi10.1371. 2013
Freischmidt, A., Hiltl, J., Kalbitzer, H. R. , and Horn-Katting, G. Enhanced in vitro translation at reduced temperatures using a cold-chock RNA motif. Biotech. Lett. 35 , 389-395. 2013
Harsch, T., Dasch, C., Donaubauer, H., Baskaran, K., Kremer, W., Kalbitzer, H. R. Stereospecific Assignment of the Asparagine and Glutamine Side Chain Amide Protons in Random-Coil Peptides by Combination of Molecular Dynamic Simulations with Relaxation Matrix Calculations. Appl. Magn. Reson. 44 , 319-331. 2013


Freischmidt , A., Liss, M., Wagner, R., Kalbitzer, H. R. and Horn, G. RNA secondary structure and in vitro translation efficiency. Prot. Express. Purif. 82 , 26–31. 2012
Koehler, J., Beck Erlach, M., Crusca Jr, E., Kremer, W., E. Munte, C. and Kalbitzer, H.R. On the pressure dependence of 15 N chemical shifts in the model peptides Ac-Gly-Gly-X-Ala-NH2. Materials 5 , 1774-1786. 2012
Kremer , W., Kalbitzer, H. R. , Schreier, C., Huber, F., Schulze, C., Daniel, H., Stolz, J. A single cell NMR membrane transport assay. Chem. Biochem. 13 , 2501-2504. 2012
Valaderes, N., de Oliveira Silva, Cavini, Í. A., R., de Almeida Marques, I., C., Andrea, S., Kalbitzer, H. R. , and Munte, C. E., Garett, R.

X-ray crystallography and NMR studies of domain swapped canecystatin-1 .

FEBS J. 280 , 1028–1038. 2012
. Koehler, J., Beck Erlach, M., Crusca Jr, E., Kremer, W., E. Munte, C. and Kalbitzer, H.R. On the pressure dependence of 15 N chemical shifts in the model peptides Ac-Gly-Gly-X-Ala-NH2. Materials 5 , 1774-1786. 2012
De Sanctis, S., Malloni, W. M., Kremer, W., Lang, E. W., Kalbitzer, H. R. Independent component analysis (ICA) and singular spectrum analysis (SSA) for solvent artifact suppression in one-dimensional NMR spectroscopy: a comparative analysis. Trends Appl. Spectr. 9 , 1-15. 2012
Cavini, Í. A., de Oliveira Silva, R., de Almeida Marques, I., Kalbitzer, H. R. , and Munte, C. E. Chemical shift assignments of the canecystatin-1 from Saccharum officinarum. NMR Ass. PMID 22696137. 2012
Rosnizeck, I. C., Spoerner, M. Filchtinski, D., Herrmann, C., Kreitner, S., Vomasta, D., König, B., and Kalbitzer, H. R. Metal BPA Complexes as State 1(T) Inhibitors of Activated Ras Protein. Chem. Int. Ed.. 51 , 10647 –10651. 2012
Axel Freischmidt , Michael Liss , Ralf Wagner , Hans Robert Kalbitzer , Gudrun Horn RNA secondary structure and in vitro translation efficiency. Protein Expression and Purification 82 (2012) 26–31 2012



Petersen, A.-K., Stark, K., Musameh, M, D., Nelson, C. P. Römisch-Margl, W., Kremer, W., Raffler, J., Krug, S., Skurk, T., Rist, M. J., Daniel, H., Hauner, H., Adamski, J., Tomaszewski, M., Döring, A., Peters, A., Wichmann, H.-E., Kaess, B. M., Kalbitzer, H. R., Huber, F., Pfahlert, V., Samani, N. J., Kronenberg, F., Dieplinger, H., Illig, T., Hengstenberg, C., Suhre, K., Giege, C., and Kastenmüller, G.

Genetic Associations with Lipoprotein Subfractions Provide Information on their Biological Nature. Hum. Mol. Gen. 21, 1433-1443. 2011

. Kremer, W., Arnold, M., Munte, C. E., Hartl, R., Beck Erlach, M., Koehler, J., Meier, A., Kalbitzer, H. R. J. Am. Chem. Soc. 133 , 13646-13651.


Pulsed Pressure Perturbations, an Extra Dimension in NMR Spectroscopy of Proteins. Am. Chem. Soc. 133 , 13646-13651. 2011
Biegerl, A., Gröger, C., Kalbitzer, H. R., Pfitzner, A., Wachter, J., Weihrich, R., and Zabel, M. Structures, spectroscopic studies and solid-state thermal transformations of coordination polymers from P 4 Se 3 and CuX (X = Cl, Br, I). J. Solid State Chem. 184 , 1719-1725. 2011
Meierhofer, T., Eberhardt, M. & Spoerner, M. Conformational states of the ADP ribosylation factor 1 complexed with different guanosine-triphosphates as studied by 31 P NMR spectroscopy. Biochemistry 50: 6316-6327 2011
Schmidt, F., Rosnizeck, I. C., Spoerner, M., Kalbitzer, H. R . and König, B. Zinc(II)cyclen Peptide Conjugates Interacting with the Weak Effector Binding States of Ras.

Inorg. Chim. Acta. 365, 38-48


Sieber, T., Scholz, R., Spoerner, M., Schumann, F., Kalbitzer, H. R. & Dobner, T. Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R. Virology 418: 133-143 2011
Meierhofer T., Rosnizeck I.C., Graf T., Reiss K., König B., Kalbitzer H R & Spoerner M. Cu 2+ -cyclen as probe to identify con formational states in guanine nucleotide binding proteins.

J. Am. Chem. Soc. 133, 2048-2051

Gröger, C., Kalbitzer, H. R ., Meier, W., Pronold, M., Scheer, M., Wachter, J., Zabel, M. Supramolecular copper halide networks using the coordinative flexibility of the cyclo-P2S3 middle deck in (C5Me5)2Mo2P2S3: Phosphorus versus sulfur coordination. Inorg. Chim. A. 370 , 191–197 2011
Schmidt, F., Spoerner, M. Kalbitzer, H. R. and König, B. Synthesis of new water-soluble cholesterol derivatives. Synth. Comm ., 41: 2876-2997 2011
Gröger, C., Kalbitzer, H. R. , Pronold, M., Piryazev, D., Scheer, M., Wachter, J., Virovets, A. and Zabel, M. Novel Metal-Organic Frameworks Incorporating [Cp°2Mo2P4S](Cp° = 1-tBu-3,4-Me2C5H2), P4S3 and Cu2I2 Building Blocks. Eur. J. Inorg. Chem. 2011 , 785–793 2011
De Sanctis, S., Malloni, W. M., Kremer, W., Tomé, A. M., Lang, E. W., Neidig, K. P. Kalbitzer, H. R. Singular Spectrum Analysis for an Automated Solvent Artifact Removal and Baseline Correction of 1D NMR Spectra. J. Magn. Reson. 210 ,177-183 2011
Ramm, P., Bettscheider, M., Beier, D., Kalbitzer, H. R., Kremer, W., Bogdahn, U., Hau, P., Aigner, L. and Beier, C. P. 1 H-NMR Spectroscopy of Glioblastoma Cancer Stem Cells. Stem Cells Develop. . 20 , 2189-95 2011
I. Rubio-Aliaga, B. de Roos, S.J. Duthie, L.K. Crosley, C. Mayer, G. Horgan, I.J. Colquhoun, G. Le Gall, F. Huber, W. Kremer , M. Rychlik, S. Wopereis, B. van Ommen, G. Schmidt, C. Heim, F.G. Bouwman, E.C. Mariman, F. Mulholland, I.T. Johnson, A.C. Polley, R.M. Elliott, & H. Daniel. Metabolomics of prolonged fasting in humans reveals new catabolic markers. Metabolomics in press Published online: 11 November 2010, DOI: 10.1007/s11306-010-0255-2 2011


Schindler, A., Balázs, G., Zabel, M., Gröger, C., Kalbitzer, H. R., Scheer, M. Coordination chemistry of [Cp*Fe( h 5 -P 3 C 2 tBu 2 )] (Cp* = h 5 -C 5 Me 5 ) with copper(I) halides – Formation of oligomeric and polymeric compounds. C. R. Chimie 13 , 1241–1248 2010
Gronwald, W. and Kalbitzer, H. R. Automated protein NMR structure determination in solution. In „Computational Biology

„Computational Biology“ (D. Fenyo, ed) Humana Press, Chapter 7, 95-127

Spoerner, M., Hozsa, C., Poetzl, J. A., Reiss, K., Ganser, P., Geyer, M., and Kalbitzer, H. R . . Conformational states of Ras protein complexed with GTP: Implications for effector binding and GTP hydrolysis. J. Biol. Chem., 285, 39768-39778 2010
Kaess, B. M., Tomaszewski, M. Braund, P. S., Stark, K., Rafelt, S., Fischer, M., Hardwick, R., Nelson, C. P., Debiec, R., Huber, F., Kremer, W., Kalbitzer, H. R ., Burton, P. R., Tobin, M. D., Hengstenberg, C., Samani, N. J Large-scale candidate gene analysis of HDL particle features. Plos One 6 :e14529 2010
Liebold, C., List, F., Kalbitzer, H.R., Sterner, R. and Brunner. E.

Xenon and Ammonia Binding to Imidazole Glycerol Phosphate Synthase from Thermotoga Maritima as detected by NMR spectroscopy.

Prot. Sci. 19 , 1774-1782. 2010
Freischmidt, A., Meysing, M., Liss, M., Wagner, R., Kalbitzer, H. R., Horn , G. Limiting factors of the translation machinery. J. Biotechnol. 150 , 44-50. 2010
Biegerl, A., Gröger, C., Kalbitzer, H. R ., Wachter, J., Zabel, M. Investigation of the coordination behaviour of P 4 D 3 towards CuBr. Z. Anorg. Allg. Chem. 2010 , 636 , 770–774 2010
Baskaran, K., Brunner, K., Munte, C. E., Kalbitzer, H. R . Mapping of protein structural ensembles by chemical shifts.

J. Biomol. NMR 48 , 71-83.

Malloni, W. M., De Sanctis, S., Tomé, A. M., Lang, E. W., Munte, C. E., Neidig, K. P. Kalbitzer, H. R . Automated solvent artifact removal and base plane correction of multidimensional NMR protein spectra by AUREMOL-SSA. J. Biomol. NMR 47, 101-111 2010
Beck Erlach, M., Munte, C. E., Kremer, W., Hartl, R., Rochelt, D., Niesner, D. and Kalbitzer, H. R. Ceramic cells for high pressure NMR spectroscopy on proteins.

J. Magn. Reson. 204 , 196-199.

Rosnizeck, I. C., Graf, T., Spoerner, M., Tränkle, J., Filchtinski, D., Herrmann, C., Gremer, L., Vetter, I. R, Wittinghofer, A., König, B., Kalbitzer, H. R. Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe. Angew. Chem. 122, 3918 –3922. 2010
Rosnizeck, I. C., Graf, T., Spoerner, M., Tränkle, J., Filchtinski, D., Herrmann, C., Gremer, L., Vetter, I. R, Wittinghofer, A., König, B., Kalbitzer, H. R. Stabilizing a weak binding state for effectors in the human Ras-protein by cyclen complexes. Angew. Chem. Int. Ed. 49 , 3830 –3833 2010


Spangler, C., Spangler, C.M., Spoerner, M. & Schäferling, M. Kinetic determination of the GTPase activity of Ras proteins by means of a luminescent terbium complex. Anal. Bioanal. Chem. 394: 989-996 2009
Baskaran, K., Kirchhöfer, R., Huber, F., Trenner, J., Brunner, K., Gronwald, W., Neidig, K.-P. and Kalbitzer, H. R. Chemical Shift Optimization in Multidimensional NMR Spectra by AUREMOL-SHIFTOPT J. Biomol. NMR 43, 197–210 2009
Linsel-Nitschke, P., Jansen, H., Aherrarhou, Z., Belz, S., Mayer, B., Huber, F., Kremer, W., Kalbitzer, H. R., Erdmann J. and Schunkert, H Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography. Lipids Health Desease 8 :14. 2009
Munte, C. E., Becker, K., Schirmer, R. H., and Kalbitzer, H. R. NMR assignments of oxidised thioredoxin from Plasmodium falciparum .

Biomol. NMR Assignments 3 , 159-161.


Schumann, F., Hoffmeister, H., Bader, R., Schmidt, M., Witzgall, R., & Kalbitzer, H. R . Ca 2+ -Dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2. J. Biol. Chem. 284 , 24372–24383 2009
Winklmeier, A., Weyand, M., Schreier, C., Kalbitzer, H. R. & Kremer, W. Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. A. Crystal. F65 , 688-691. 2009
Schreier, C., Auer, A., Kalbitzer, H. R. and Kremer, W. NMR Assignments of a 48 kDa Tetramer of the T1 Domain of the mammalian Voltage Gated Potassium Channel Kv1.4. Kv1.4. Biomol. NMR Assignments 3 , 167-170. 2009
Schumann, F. H., Hoffmeister, H., Schmidt, M., Bader, R., Besl, E., Witzgall, R. and Kalbitzer, H. R. NMR-Assignments of a Cytosolic Domain of the C-Terminus of Polycystin-2. Biomol. NMR Assignments 3 , 141-144. 2009
Kalbitzer, H. R ., Spoerner, M., Ganser, P. and Kremer, W. A fundamental link between folding and function as studied by high pressure NMR spectroscopy of the Ras protein. J. Am. Chem. Soc. , 131 , 16714–16719. 2009
Cano, C., Brunner, K. Elsner, R., Baskaran, K., Munte, C. E. and Kalbitzer, H. R. Protein structure calculation with data imputation: the use of substitute restraints. J. Biomol. NMR 45 , 397-411. 2009
Kiel, C., Filchtinski, D., Spoerner, M., Schreiber, G., Kalbitzer, H. R. and Herrmann,C. Improved binding of Raft o Ras-GDP is correlated with biological activity.

J. Biol. Chem. 284 , 31893-31902.



J. Ramírez, J. M. Górriz, M. Gómez-Río, A. Romero, R. Chaves, A. Lassl, A. Rodríguez, C. G. Puntonet, F. Theis, E. Lang Effective Emission Tomography Image Reconstruction Algorithms for SPECT Data Proc. ICCS 2008, 741 – 748, (2008) 2008
Ch. Kohler, I. Keck, Ch.-H. Lie, P. Gruber, K. Specht, A. M. Tomé, E. W. Lang Spatiotemporal group ICA applied to fMRI datasets Proc. IEEE-EMBC 2008, pp. 4652 – 4655, (2008) ISBN: 978-4244-1815-2, ISSN: 1557-170X 2008

A. R. Teixeira, A. M. Tomé, E. W. Lang , A. Martins da Silva

Subspace techniques to remove artifacts from EEG: A quantitative analysis

Proc. IEEE-EMBC 2008, pp. 4395 – 4398, (2008) ISBN: 978-4244-1815-2, ISSN: 1557-170X

F. Fink, K. Wörle, P. Gruber, A. M. Tomé, J. M. Górriz Sáez, C. G. Puntonet, E. W. Lang ICA analysis of Retina images for Glaucoma classification Proc. IEEE-EMBC 2008, pp. 4664 – 4667, (2008) ISBN: 978-4244-1815-2, ISSN: 1557-170X 2008
D. Herold, D. Lutter, R. Schachtner, A. M. Tomé, G. Schmitz, E. W. Lang Comparison of Unsupervised and Supervised Gene Selection Methods

Proc. IEEE-EMBC 2008, pp. 5212 – 5215, (2008) ISBN: 978-4244-1815-2, ISSN: 1557-170X

R. Schachtner, D. Lutter, A. M. Tomé, G. Schmitz, P. Gómez Vilda, E. W. Lang A Matrix Factorization Classifier for Knowledge-based Microarray Analysis

Advances in Soft Computing 49 , 137 – 147, (2008)


A. R. Teixeira, A. M. Tomé, E. W. Lang

Feature extraction using low rank approximations of the Kernel matrix LNCS 5112 , 404 – 412, (2008) 2008

K. Stadlthanner, F. J. Theis, E. W. Lang , A. M. Tomé, C. G. Puntonet, J. M. Górriz Sáez

Hybridizing sparse component analysis with genetic algorithms for Microarray analysis

Neurocomputing (2008), 71 , 2356-2376  

A.R. Teixeira, A. M. Tomé, K. Stadlthanner, E. W. Lang

Denoising and the Pre-image problem revisited

Digital Signal Processing, 18 , 568 – 590, (2008) 2008
A. R. Teixeira, A. M. Tomé, M. Böhm, C. G. Puntonet , E. W. Lang

How to apply non-linear subspace techniques to Univariate biomedical time series

IEEE Trans Instrum. Measurement 2008, in print 2008

Ch. Kohler, Chuh-Hyoun Lie, I. R. Keck, P. Gruber, K. Specht, E. W. Lang

Spatiotemporal group ICA applied to a Wisconsin card sorting test experiment IEEE Trans. Neural Networks 2008, revision under review 2008
D. Lutter, Th. Langmann, P. Ugocsai, C. Moehle, E. Seibold, W. Splettstoesser, P. Gruber, E. W. Lang , G. Schmitz Analyzing Time-dependent Microarray Data Using Independent Component Analysis Derived Expression Modes from Human Macrophages Infected with F. tularensis holartica J. Medical Informatics, accepted 2008
D. Lutter, P. Ugocsai, M. Grandl, E. Orso , F. J. Theis, E. W. Lang Analyzing M-CSF dependent monocytes – macrophage differentiation and meta-clustering with independent component analysis derived expression modes BMC Bioinformatics, 2008, 9, 100 2008
R. Schachtner, D. Lutter, P. Knollmüller, A. M. Tomé, F. J. Theis, G. Schmitz, M. Stetter, P. Gómez Vilda, E. W. Lang Knowledge-based Gene expression Classification via Matrix Factorization Bioinformatics, 2008, 24(15):1688-1697 2008
E. W. Lang, R. Schachtner, D. Lutter, D. Herold, Ph. Knollmüller, F. Theis, G. Schmitz, A. M. Tomé, P. Gómez Vilda, C. G. Puntonet, J. M. Górriz Sáez, M. Stetter, Machine Learning Techniques to Identify Marker Genes for Diagnostic Classification of Microarrays in Machine Learning Research Progress, H. Peters, M. Vogel, eds., Nova Science Publishers, Chapter 1, pp. 1 – 65, 2008, in press 2008
Gröger, C., Lutz, K., Brunner, E. NMR Studies on Biomineralization. Progress in Nuclear Magnetic Resonance Spectroscopy, 54 (2009) 54-68 2008
Sumper, M., Brunner, E. Silica Biomineralization if Diatoms: The Model Organism Thalassiosira pseudonana. ChemBioChem 9 , 1187-1194. 2008
Gröger, C., Sumper, M., Brunner, E. Silicon uptake and metabolism of the marine diatom Thalassiosira pseudonana: Solid-state 29 Si NMR and fluorescence microscopic studies. J. Struct. Biol. 161 , 55-63. 2008
Gröger, C., Lutz, K., Brunner, E. Biomolecular Self-assembly and ist Relevance in Silica Biomineralization. Cell Biochemistry and Biophysics 50 , 23-39. 2008
Ramm , P., Plötz, S., Couillard-Despres, S., Rivera, F., Krampert, M., Lehner, B., Kremer, W., Bogdahn, U., Kalbitzer , H. R. & Aigner, L. A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis? Stem Cells , 27 , 420-423 2008
Sasaki, K., Gaikwad, J., Hashiguchi, S. Kubota , T., Sugimura, K. Kremer, W., Kalbitzer, H. R. and Akasaka, K. Reversible monomer-oligomer transition in human prion protein. Prion 2, 118-122 2008
Seitz, C., Eberle, W., Kalbitzer, H. R. , & Knoll, M. Evidence for a cystein proteinase involved in BSE infection and/or progression. Biochemica 3 , 26-27. 2008
Riepl, H., Maurer, T., Kalbitzer, H. R., Meier, V. M., Haslbeck, M., Schmitt, R. & Scharf, B. Interaction of CheY2 and CheY2-P with the cognate CheA kinase in the chemosensory-signalling chain of Sinorhizobium meliloti. Mol. Microbiol. 69 , 1373-1384.  
Gronwald, W. Bombke, J., Maurer, T., Domogalla, B., Huber, F., Schumann, F., Kremer, W., Fink, F., Rysiok, T., Frech, M. & Kalbitzer, H. R. Structure of the Leech Protein Saratin and Characterisation of its Binding to Collagen. J. Mol. Biol . 381 , 913–927. 2008
Munte, C. E., Gäde, G., Domogalla, B., Kremer, W., Kellner, R., & Kalbitzer, H. R. C-mannosylation in the hypertrehalosaemic hormone (HrTH) from the stick insect Carausius morosus FEBS J . 275, 1163-1173. 2008
Kaess, B., Fischer, M., Baessler, A., Stark, K., Huber, F., Kremer, W., Kalbitzer, H. R ., Schunkert, H., Riegger, G., Hengstenberg, C. The lipoprotein subfraction profile: heritability and identification of quantitative trait loci. Journal of Lipid Research, Vol. 49, 715-723, April 2008 2008
Brügger, B., Krautkrämer, E., Tibroni, N., Munte, C. E., Rauch, S., Leibrecht, I., Glass, B., Bräuer, S., Geyer, M., Kräusslich, H.-G., Kalbitzer, H.R ., Wieland, F.T. and Fackler, O.T. Human Immunodeficiency Virus Type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovir. 4: 70, 1-12. 2007
Rudolph, C., Sigruener, A., Hartmann, A., Bals-Pratsch, M., Gronwald, W, Seifert, B., Kalbitzer, H. R., Verdorfer, I., Luetjens, C. M., Ortmann, O., Bornstein, S. R. & Schmitz , G. ApoA-I Binding Protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. Horm. Metab. Res. 39 , 322-335. 2007
Kremer, W., Kachel, N., Kuwata, K., Akasaka, K., & Kalbitzer, H. R. Species specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy. J. Biol. Chem. 282, 22689–22698. 2007
Schumann, F. H., Riepl, H., Maurer, T., Gronwald, W., Neidig, K.-P., & Kalbitzer, H. R. Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions. J. Biomol. NMR 39, 275–289. 2007
Horn, G., Hofweber, R., Kremer, W. & Kalbitzer, H. R. Structure and function of bacterial cold shock proteins. Cell. Mol. Life Sci. 64, 1457 – 1470. 2007
Sterner, R., Brunner, E.

The relationship between catalytic activity, structural flexibility and conformational stability as deduced from the analysis of mesophilic-thermophilic enzyme pairs and protein engineering studies.

Thermophiles, Biology and Technology at High Pressures", CRC Press 2008, 25-38. 2007

Blobel, J., Schmidl, S., Vidal, D., Nisius, L., Bernadó, P., Millet, O., Brunner, E., Pons, M.

Protein tyrosine phosphatase oligomerization studied by a combination of 15N-NMR relaxation and 129Xe-NMR. The effect of arginine and glutamic acid containing buffer.

J. Am. Chem. Soc. 129 (2007) 5946-5953. 2007
Kalbitzer H.R., Kremer W., Schumann F., Spörner M., Gronwald W. Elucidation of Protein-Protein and Protein-Ligand Interactions by NMR-Spectroscopy. Protein Interactions -Biophysical Approaches for the Study of Complex Reversible Systems. (Ed. by Schuck P.) Springer Verlag. ISBN: 978-0-387-35965-6
pp. 189-230
Ader, C., Spoerner, M., Kalbitzer, H.R., Brunner, E. Solid-State 31 P NMR Spectroscopy of Precipitated Guanine Nucleotide-Binding Protein Ras in Complexes With its Effector Molecules Raf Kinase and RalGDS. J. Phys. Chem. B, 111, 2752-2757 2007
Iuga, A., Ader, C., Gröger, C., Brunner, E. Applications of solid-state 31 P NMR spectroscopy. Annu. Rep. NMR Spectrosc. 60 (2007) 145-189. 2007
Kalbitzer, H. R. & Petrides, P. E. Kap. 3 Proteine . In: „Biochemie und Pathobiochemie“ (L. Löffler, Petrides, & Heinrich, eds), pp. xx to xx, 8 th edition, Springer Verlag, Heidelberg, in press. 2007
Gronwald, W., Brunner, K., Kirchhöfer, R., Trenner, J., Neidig, K.-P. & Kalbitzer, H.R. AUREMOL-RFAC-2D, combination of R-factors and their use for automated quality assessment of protein structures. J J Biomol NMR. 2007 Jan;37(1):15-30. 2007
Spoerner, M., Nuehs, A, Herrmann, C., Steiner, G. & Kalbitzer, H. R. Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgS. FEBS J 274 (6), 1419-1433. 2007
Kremer, W. High-Pressure NMR Studies in Proteins. Ann. Rep. NMR Spectroscopy, 57, 177-200. 2006
Ab, E., Atkinson, A. R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., Diercks, T., Dötsch, V., Engelke, F., Folkers, G. E., Griesinger, C., Gronwald, W., Günther, U., Habeck, M., de Jong, R., N., Kalbitzer, H. R. , Kieffer, B., Leeflang, B. R., Loss, S., Luchinat, C., Marquardsen, T., Moskau, D., Neidig, K.-P., Nilges, M., Piccioli, M., Pierattelli, R., Rieping, W., Schippmann, T., Schwalbe, H., Travé, G., Trenner, J., Wöhnert, J., Zweckstetter, M. and Kaptein, R. NMR in the SPINE Structural Genomics project. A. Cryst. D62 , 1150-1161. 2006
Baumer D., Brunner E., Blümler P., Zänker P.P., Spiess H.W.

NMR spectroscopy of laser-polarised 129 Xe under continuous flow:

A method to study aqueous solutions of biomolecules.

Angew. Chem. Int. Ed. 45 (2006) 7282-7284. 2006
Brunner E., Lutz K. Solid-state NMR in biomimetic silica formation and silica biomineralisation.

Handbook of Biomineralisation, Vol. 2 (Hrsg.: P. Behrens/ E. Bäuerlein),Wiley-VCH, im Druck

Iuga A., Ader C., Gröger C., Brunner E. Applications of solid-state 31 P NMR spectroscopy.

Annu. Rep. NMR Spectrosc. 60 ( 2007) 145-189.

Kachel N., Kremer W., Zahn R., Kalbitzer H.R. Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy. BMC Struct Biol. 2006 Jul 17;6(1):16 2006
Brunner K., Gronwald W., Trenner J.M., Neidig K.P., Kalbitzer H.R. A general method for the unbiased improvement of solution NMR structures by the use of related x-ray data, the AUREMOL-ISIC algorithm. BMC Struct Biol. 2006 Jun 26;6(1):14 2006
Iuga A., Spoerner M., Ader C., Brunner E., Kalbitzer H.R. Rapid assignment of solution 31P NMR spectra of large proteins by solid-state spectroscopy. Biochem. Biophys. Res. Commun. 346, 309-313. 2006
Sumper M., Brunner E. Learning from diatoms: Nature's tools for the production of nanostructured silica. Adv. Funct. Mater. 16, 17-26. 2006
Bennati M., Hertel M. M.,Fritscher J., Prisner T. F., Weiden N., Hofweber R., Spoerner M., Horn G., & Kalbitzer H.R. High-frequency 95 GHz ENDOR Characterization of the Metal Binding Sites in Wild Type Ras.GDP and its Oncogenic Mutant G12V in Frozen Solution. Biochemistry 45 , 42-50. 2006
Stadlthanner K., Tomé A. M., Theis F. J., Lang E. W., Gronwald W. & Kalbitzer H. R. Separation of water artefacts in 2D NOESY protein spectra using congruent matrix pencils. Neurocomp. 96 , 497-522. 2006
Böhm M., Stadlthanner K., Gruber P., Theis F. J., Lang E. W., Tom, A. M., Teixeira, Gronwald W. & Kalbitzer H. R. On the use of simulated annealing to automatically assign independent components. IEEE Transact. Biomed. Engineer. 2006
Nisius L., Stadler M., Kalbitzer H.R., Brunner, E. NMR spectroscopic study of noble gas binding into the engineered cavity of HPr(I14A) from Staphylococcus carnosus J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2005 Sep 29;109(38):17795-8 2005
Fink, A., Baumer, D., Brunner, E. Production of hyperpolarized xenon in a static pump cell: Numerical simulations and experiments. Phys. Rev. A 72 web release number 053411. 2005
Lutz, K., Gröger, C., Sumper, M., Brunner, E. Biomimetic silica formation: Analysis of phosphate-induced self-assembly of polyamines. Physical Chemistry Chemical Physics 7 2812-2815. 2005
Sumper, M., Brunner, E., Lehmann, G. Biomineralization in diatoms: Characterization of novel polyamines associated with silica. FEBS Letters 579 3765-3769. 2005
Möglich, A., Weinfurtner, D., Gronwald, W., Maurer, T. & Kalbitzer, H. R. PERMOL: Restraint-based protein homology modeling using DYANA or CNS. Bioinform. 21 , 2110-2111. 2005
Möglich, A., Weinfurtner, D., Maurer, T., Gronwald, W. & Kalbitzer, H. R. A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles. BMC Bioinform . 6 :91. 2005
Riepl, H., Hartl, R. ,Bauer, M., Nar, H., Kauschke, S. G., Kalbitzer, H. R. & and Maurer, T. Sequential Backbone Assignment of Peroxisome Proliferator-Activated Receptor g Ligand Binding Domain. J. Biomol. NMR. 32 , 259-259. 2005
Munte, C. E., Vilela, L., Kalbitzer, H. R. & Garratt, R. C. Solution Structure of Human Proinsulin C-Peptide. FEBS J. 272 , 4284-4293. 2005
Munte, C. E., Becker, K., Schirmer, R. H. & Kalbitzer, H. R. 1 H, 13 C, and 15 N sequence-specific resonance assignme nt and secondary structure of Plasmodium falciparum thioredoxin . J. Biomol. NMR 32 , 340-340. 2005
Hofweber, R., Horn, G., Langmann, T., Balbach, J., Kremer, W., Schmitz, G. & Kalbitzer, H. R. The influence of cold shock proteins on transcription and translation studied in cell-free model systems. FEBS J . 272 , 4691-4702. 2005
Nisius, L., Stadler, M., Kalbitzer, H. R. & Brunner, E. NMR-Spectroscopic Study of Noble Gas-binding into the Engineered Cavity of HPr(I14A) from Staphylococcus carnosus. J. Chem. Phys. 109 , 17795-17798. 2005

M. Spoerner, T.F. Prisner, M. Bennati, M.M. Hertel, N. Weiden, T.Schweins & H.R. Kalbitzer

Conformational States of Human H-Ras Detected by High field EPR, ENDOR, and 31P NMR Spectroscopy.

Magn. Reson. Chem. , 43 , 74-83


M. Spoerner, T. Graf, B. König, H.R. Kalbitzer

A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules.

Biochem. Biophys. Res. Commun. , 334 , 709-713


J.P. Geyer, R. Döker, W. Kremer, X. Zhao, J. Kuhlmann and H.R. Kalbitzer

Solution Structure of the Ran-binding Domain 2 of RanBP2 and its Interaction with the C Terminus of Ran.

J Mol Biol , 348 , 711-725


M. Spoerner, A. Nuehs, P. Ganser, C. Herrmann, A. Wittinghofer, H.R. Kalbitzer

Conformational States of Ras Complexed with the GTP-analogs GppNHp or GppCH2p: Implications for the Interaction with Effector Proteins.

Biochemistry , 44 , 2225-2236


Meier M., Fink A., and Brunner E.

Reverse Micelles Dissolved in Supercritical Xenon: An NMR Spectroscopic Study.

J. Phys. Chem. B , 109, 3494-3498


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Es tut sich was!

35 th FGMR Discussion Meeting and Joint Conference

The meeting will be held from September 9 to 12, 2013 in Frauenwörth on the island of Frauenchiemsee / Lake Chiemsee southeast of Munich, Germany.


Freie Stellen für wache Köpfe

Am Lehrstuhl sind laufend Diplom- und Doktor-arbeiten in physikalischen, biologischen, chemischen und biochemischen Bereichen zu vergeben.
Interessenten melden sich bei Prof. Kalbitzer und / oder Mitarbeitern oder im Sekretariat,
Tel: 0941 - 943 2595