Use of high pressure for the study of
conformational states and dynamics in biological systems
The core-to-core program "Use of high pressure for the study of conformational states and dynamics in biological systems" constitutes an international network of research institutions focused on high pressure effects on biological macromolecules and macromolecular. In Germany the program is funded by the Deutsche Forschungsgemeinschaft. Main partners here are the University of Regensburg (Institute of Biophysics and Physical Biochemistry) with the German core centre and the University of Dortmund (Institute for Physical Chemistry). The program is to promote the use of new experimental techniques such as high-pressure high-field NMR spectroscopy by researchers in the core institutions abroad and to perform collaborative research on their proteins. Young investigators and students are supported to visit core institutions abroad to learn different experimental techniques related to pressure. International workshops will be held to deepen the understanding how pressure reveals nature's design of biological macromolecules such as proteins both structurally and thermodynamically and how this design is to be used in applications.
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