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We are delighted to host the 5 th International Meeting on Biomolecules under Pressure in Regensburg. The meeting is supposed to be a platform for stimulating discussions on using high pressure techniques to study and manipulate biomolecules. The program is open to questions from a broad range of research areas including protein folding, the molecular basis of adaptation of life to extreme conditions, protein aggregation and the formation of amyloid fibers, dissociation of oligomeric proteins and applications of high pressure in biotechnology and medicine.

We look forward to bringing together as many researchers with different backgrounds as possible!

Best regards,

Hans Robert Kalbitzer, Meeting Organizer

Following speakers have agreed to lecture:

Speaker
Country
Topic
C. Royer
France
Answering Kauzmann's complaint: A quantitative parameterization of
volume changes for protein folding
T. Kiefhaber
Germany The effect of pressure on protein folding kinetics reveals details of the folding free energy landscape
H. Tachibana Japan

Changes of volumetric properties of fibrils with maturation and those with disulfide-bridging

K. Akasaka Japan Manipulation of amyloid fibrils by pressure
R. Lange France Climbing opposite faces of energy barriers via protein relaxation kinetics under high pressure
W. Doster Germany Pressure Tuning of Biomolecular Complexes
O. Zerbe Switzerland Studies of unfolding of a mini-protein using mutagenensis, temperature, solvent and pressure
S. Schwarzinger Germany Epitope binding to the anti-prion active antibody fragment scFv-W226 studied by
paramagnetic relaxation enhanced NMR-spectroscopy
J. Balbach Germany Time resolved NMR spectroscopy to study protein folding
D. Pearson England Pressure Jump in Muscle Research; Calcium and TnC
A. Garcia USA Exploring the energy landscape of proteins and RNA oligomers
R. Fourme France Isothermal compressibility of macromolecular crystals and macromolecules determined by high-pressure macromolecular crystallography
K. Soda Japan Analysis of Volume-Fluctuation Dynamics of Proteins and Pressure Effects
H. R. Kalbitzer Germany High pressure NMR spectroscopy: Detection of intermediate states
C. Roumestand France Tracking dynamical conformational states in ∆+PHS+V66K Staphyloccocal nuclease variant with NMR spectroscopy.
R. Winter Germany Using Pressure Perturbation for Studying the Free Energy and Conformational Landscape of Proteins Upon Aggregation and Amyloid Formation
L. Smeller Hungary Kinetic studies of pressure mediated folding-unfolding and aggregation processes by FTIR and fluorescence spectroscopy
W. Kremer Germany What high pressure can tell us about structural transients of the prion protein



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