Prof. Dr. Dr. Hans Robert Kalbitzer
    Institut für Biophysik und physikalische Biochemie
    Universität Regensburg
    D-93040 Regensburg

    Telefon: +49 (0)941 943-2594
    Telefax: +49 (0)941 943-2479
    e-mail: hans-robert.kalbitzer@biologie.uni-regensburg.de

 

 

Publications (without abstracts)

Books, contributions to books and reviews are labelled by “B”, abstracts are not contained in the publication list

1. Kalbitzer, H. R., Stehlik, D. & Hasselbach, W. (1978) The Binding of Calcium and Magnesium to Sarcoplasmic Vesicles as Studied by Manganese Electron Paramagnetic Resonance. Eur. J. Biochem. 82 , 245-255.

 2. Kalbitzer, H. R. & Stehlik, D. (1979) On the Analysis of Competitive Binding of Various Ligands to Cooperative and Independent Binding Sites of Macromolecules. Z. Naturforsch. 34c , 757-769.

3. Rösch, P., Kalbitzer, H. R. & Goody, R. S. (1980) 31 P NMR Spectra of Thiophosphate Analogues of Guanosine Nucleotides. pH Dependence of Chemical Shifts and Coupling Constants. FEBS Lett. 121 , 211-214.

 4. Rösch, P., Kalbitzer, H. R., Schmidt-Aderjan, U. & Hengstenberg, W. (1981) 1 H Nuclear Magnetic Resonance Studies on the Structure and Mechanism of the HPr Protein of Staphylococcus aureus . Biochemistry 20 , 1599-1605.

5. Rösch, P., Kalbitzer, H. R. & Goody, R. S. (1981) 18 O-Exchange by Hydrolyzing Enzymes: An ab initio Calculation. Z. Naturforsch. 36c , 534-538.

6. Antonsson, B., Kalbitzer, H. R. & Wittinghofer, A. (1981) The Binding of Nucleotides and Metal Ions to Elongation Factor Tu from Bacillus stearothermophilus as Studies by Equilibrium Dialysis. Hoppe-Seyler's Z. Physiol. Chem. 362 , 735-743.

7. Kalbitzer, H. R. & Rösch, P. (1981) The Effect of Phosphorylation of the Histidyl Residue in the Tetrapeptide Gly-Gly-His-Ala. Changes of Chemical Shift and pK-Values in 1 H- and 31 P-NMR Spectra. Org. Magn. Reson. 17 , 88-91.

8. Rösch, P., Goody, R. S., Kalbitzer, H. R. & Zimmermann, H. (1981) The Interaction of Myosin S1 with Phosphorothioates of ADP: An 18 O Exchange Study by 31 P NMR. Arch. Biochem. Biophys. 211 , 622-627.

9. Kalbitzer, H. R., Deutscher, J., Hengstenberg, W. & Rösch, P. (1981). Phosphoenolpyruvate-Dependent Phosphotransferase System of Staphylococcus aureus : 31 H Nuclear Magnetic Resonance Studies on Phosphorylated and Unphosphorylated Factor III lac and Its Interaction with the Phosphocarrier Protein HPr. Biochemistry 21 , 6178-6185.

10. Wittinghofer, A., Goody, R. S., Rösch, P. & Kalbitzer, H. R. (1982) The Structure of the EF-Tu.GDP.Me 2+ Complex. Eur. J. Biochem. 124 , 109-115.

11. Kalbitzer, H. R., Hengstenberg, W., Rösch, P., Muss, P., Bernsmann, P., Engelmann, R., Dörschug, M. & Deutscher, J. (1982) HPr-Proteins of Different Microorganisms Studied by Hydrogen-1 High-Resolution Nuclear Magnetic Resonance: Similarities of Structures and Mechanisms. Biochemistry 21 , 2879-2885.

12. Kalbitzer, H. R., Marquetant, R., Rösch, P. & Schirmer, R. H. (1982) The Structural Isomerisation of Human Adenylate Kinase as Studied by 1 H Nuclear Magnetic Resonance. Eur. J. Biochem. 126 , 531-536.

13. Kalbitzer, H. R., Marquetant, R., Connolly, B. A., Goody, R. S. (1983) Structural Investigations of the Mg.ATP Complex at the Active Site of Porcine Adenylate Kinase Using Phosphorothioate Analogs and Mn(II)-EPR with Chiral 17 O-labelled Analogs. Eur. J. Biochem. 133 , 221-227.

 14. Kalbitzer, H. R., Goody, R. S. & Wittinghofer, A. (1984) Electron Paramagnetic Resonance Studies of Manganese (II) Complexes with Elongation Factor Tu from Bacillus stearothermophilus . Observation of a GTP Hydrolysis Intermediate State Complex. Eur. J. Biochem. 141 , 591-597.

15. Dörschug, M., Frank, R., Kalbitzer, H. R. , Hengstenberg, W. & Deutscher, J. (1984) Phosphoenolpyruvate-Dependent Phosphorylation Site in Enzyme III glc of Escherichia coli Phosphotransferase System. Eur. J. Biochem. 144 , 113-119.

16. Neidig, P., Bodenmüller, H. & Kalbitzer, H. R. (1984) Computer Aided Evaluation of Two-Dimensional NMR Spectra of Proteins. Biochem. Biophys. Res. Comm. 125 , 1143-1150.

17. Kalbitzer, H. R. , Lebermann, R. & Wittinghofer, A. (1985) 1 H-NMR Spectroscopy on Elongation Factor Tu from Escherichia coli . Resolution Enhancement by Perdeuteration. FEBS Lett. 180 , 40-42.

18. Kalbitzer, H. R. , Muss, H. P., Engelmann, R., Kiltz, H. H., Stüber, K. & Hengstenberg, W. (1985) Phosphoenolpyruvate-Dependent Phosphotransferase System. 1 H NMR Studies on Chemically Modified HPr Proteins. Biochemistry 24 , 4562-4569.

19. Sontheimer, G. M., Kuhn, W. & Kalbitzer, H. R. (1986) Observation of Mg 2+ .ATP and Uncomplexed ATP in Slow Exchange by 31 P-NMR at High Magnetic Fields. Biochem. Biophys. Res. Comm. 134 ,1379-1386.

20. Glaser, S. & Kalbitzer, H. R. (1986) Improvement of 2D NMR Spectra by Mean t 1 Ridge Subtraction and Antidiagonal Reduction. J. Magn. Reson. 68 , 350-354.

21. Feuerstein, J., Kalbitzer, H. R. , John, J., Goody, R. S. & Wittinghofer, A. (1987) Characterization of the Metal Ion GDP Complex at the Active Sites of Transforming and Non-Transforming p21 Proteins by Observation of the 17 O- 55 Mn Superhyperfine Coupling and by Kinetic Methods. Eur. J. Biochem. 162 , 49-55.

22. Sontheimer, G. M., Kalbitzer, H. R. & Hasselbach, W. (1987) The Phosphorylation of the Sarcoplasmic Calcium-Activated Adenosinetriphosphatase as Studied by 31 P Nuclear Magnetic Resonance. Biochemistry 26 , 2701-2706.

23. Glaser, S. & Kalbitzer, H. R. (1987) Automated Recognition and Assessment of Cross Peaks in Two-Dimensional NMR Spectra of Macromolecules. J. Magn. Reson. 74 , 430-436.

B24. Kalbitzer, H. R. (1987) Identification of Oxygen Ligands in Metal-Nucleotide-Protein Complexes by Observation of the Mn(II)- 17 O Superhyperfine Coupling.

In 'Metal Ions in Biological Systems' (H. Sigel, ed.) Vol. 22 , 81-103, Marcel Dekker Inc, New York .

25. Groß, K.-H. & Kalbitzer, H. R. (1988) Distribution of Chemical Shifts in 1 H Nuclear Magnetic Resonance Spectra of Proteins. J. Magn. Reson. 76 , 87-99.

26. Schlemmer, H., Sontheimer, G. M. & Kalbitzer, H. R. (1988) 31 P Nuclear Magnetic Resonance Spectroscopy of the Phosphorylated Tetrapeptide Gly-Gly-Asp-Ala. Magn. Reson. Chem. 26 , 260-263.

27. Neidig, K.-P. & Kalbitzer, H. R. (1988) Improvement of 2D NMR Spectra by Matching Symmetry-Related Spectral Features. Magn. Reson. Chem. 26 , 848-851.

 28. Saffrich, R., Kalbitzer, H. R. , Bodenmüller, H., Muhn, P., Pipkorn, R. & Schaller, H. C. (1989) 1 H Nuclear Magnetic Resonance Studies of the Neuropeptide Head Activator. Biochim. Biophys. A. 997 , 144-153.

29. Hengstenberg, W., Reiche, B., Eisermann, R., Fischer, R., Keßler, U., Tarrach, A., De Vos, W. M., Kalbitzer, H. R. & Glaser, S. (1989) Structure and Function of Proteins Involved in Sugar Transport by PTS of Gram-Positive Bacteria. FEMS Microbiol. Rev. 63 , 35-42.

B30. Hausser, K. H. & Kalbitzer, H. R. (1989) NMR für Mediziner und Biologen. Strukturbestimmung, Bildgebung, In-Vivo-Spektroskopie. Springer Verlag, Heidelberg .

31. Kalbitzer, H. R. , Feuerstein, J., Goody, R. S. & Wittinghofer, A. (1990) Stereochemistry and Lifetime of the GTP Hydrolysis Intermediate in the Active Site of Elongation Factor Tu from Bacillus stearothermophilus as Inferred from the 17 O- 55 Mn Superhyperfine Interaction. Eur. J. Biochem. 188 , 355-359.

32. Neidig, K.-P. & Kalbitzer, H. R. (1990) Improved Representation of 2D NMR Spectra by Local Rescaling. J. Magn. Reson. 88 , 155-160.

33. Kalbitzer, H. R. , Neidig, K.-P. & Hengstenberg, W. (1990) Structure Determination of Polypeptides and Proteins by Two-Dimensional NMR Spectroscopy. Physica B 164 , 180-192.

34. Neidig, K.-P., Saffrich, R., Lorenz, M. & Kalbitzer, H. R. (1990) Cluster Analysis and Multiplet Pattern Recognition in Two-Dimensional NMR spectra. J. Magn. Reson. 89 , 543-552.

35. Mitchang, L., Neidig, K.-P. & Kalbitzer, H. R. (1990) Suppression of Oscillatory Artifacts in Two-Dimensional NMR spectra. J. Magn. Reson. 90 , 359-362.

36. Neidig, K.-P. & Kalbitzer, H. R. (1991) Enhancement of Global Symmetries in Two-Dimensional NMR Spectra. J. Magn. Reson. 91 , 155-164.

37. Kalbitzer, H. R. & Wittinghofer, A. (1991) The Effect of Kirromycin on the Metal Ion Coordination in Complexes of Elongation Factor Tu from Bacillus stearotherrophilus as Inferred from the 17 O- 55 Mn Superhyperfine Interaction. Biochim. Biophys. A. 1078 , 133-138.

38. Maeda, K., Rösch, A., Maéda, Y., Kalbitzer, H. R. & Wittinghofer, A. (1991) Rabbit Skeletal Muscle Myosin: Unfolded Carboxyl Terminus and its Role in Molecular Assembly. FEBS Lett. 281 , 23-26.

39. Finkeldai, U., Kalbitzer, H. R. , Eisermann, R., Stewart, G. C. & Hengstenberg, W. (1991) Enzyme III lac of the Staphylococcal Phosphoenolpyruvate Dependent Phosphotransferase System: Site-Directed Mutagenesis, Biochemical Characterization and 1 H-NMR-Studies. Prot. Engin. 4 , 469-473.

40. Kalbitzer, H. R. , Maeda, K., Rösch, A., Maéda, Y., Geyer, M., Beneicke, W., Neidig, K.-P. & Wittinghofer, A. (1991) C-terminal Structure and Mobility of Rabbit Skeletal Muscle Light Meromyosin as Studied by One- and Two-Dimensional 1 H NMR Spectroscopy and X-Ray Small-Angle Scattering. Biochemistry 30 , 8083-8091.

41. Kalbitzer, H. R. , Neidig, K.-P. & Hengstenberg, W. (1991) Two-Dimensional 1 H-NMR Studies on HPr Protein from Staphylococcus aureus : Complete Sequential Assignments and Secondary Structure. Biochemistry , 30 , 11186-11192.

B42. Kalbitzer, H. R. , Neidig, K.-P., Geyer, M., Saffrich, R. & Lorenz, M. (1991)

Pattern Recognition in Two-Dimensional NMR Spectra of Proteins. In 'Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance´ (J.C. Hoch, ed.) pp 175-190, Plenum Press, New York .

B43. Hausser, K. H. & Kalbitzer, H. R. (1991) NMR in Medicine and Biology. Structure Determination, Tomography, In Vivo Spectroscopy Springer Verlag, Heidelberg .

44. Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, H. R., Kalbitzer, H. R. & Wittinghofer, A. (1992) Expression, Purification and Biochemical Characterisation of the Human Immunodeficiency Virus 1 Nef Gene Product. Eur. J. Biochem. 205 , 1115-1121.

45. Kalbitzer, H. R. , Rohr, G., Nowak, E., Goody, R. S., Kuhn, W. & Zimmermann, H. (1992) A New High-Sensitivity 19 F Probe for Labeling Cysteine Groups of Proteins. NMR Biomed. 5 , 347-350.

46. Rohr, G., Eggert-Kruse, W., Pehlke, A. , Sahrbacher, U., Runnebaum, B. & Kalbitzer, H. R. (1992) Biochemical Analysis of Cervical Mucus by Nuclear Magnetic Resonance (NMR) Spectroscopy. Hum. Reprod. 7 , 915-917.

47. Kalbitzer, H. R. , Schrumpf, M. & Wray, J. (1992) High Protein Mobility in Skinned Rabbit Muscle Fibers Observed by 1 H NMR Spectroscopy. FEBS Lett. 298 , 226-228.

48. Kalbitzer, H. R. (1992) Max-Planck-Scientist offers European Perspective on Protein NMR Databases: State-of-the-Art and Future Directions in Europe . Chem.Des.Autom.N. 7 , 16.

49. Kalbitzer, H. R. & Hengstenberg, W. (1992) The Solution Structure of the Histidine-Containing Protein (HPr) from Staphylococcus aureus as determined by Two-Dimensional 1 H-NMR Spectroscopy. Eur.J.Biochem. 216 , 205-214.

50. Saffrich, R. , Beneicke, W., Neidig, K.-P. & Kalbitzer, H. R. (1993) Baseline Correction in n-Dimensional NMR Spectra by Sectionally Linear Interpolation. J. Magn. Reson . B 101 , 304-308.

51. Hengstenberg, W., Kohlbrecher, D., Witt, E., Kruse, R., Christiansen, I., Peters, D., von Strandmann, R. P., Städler, P., Koch, B., and Kalbitzer, H. R. (1993) Structure and Function of the Proteins of the Phosphotransferase System and of 6-Phospho- b -Glycosidases in Gram-Positive Bacteria. FEMS Microbiol. Rev. 12 , 149-164.

52. Kruse, R., Hengstenberg, W., Beneicke, W. & Kalbitzer, H. R. (1993) Involvement of Various Amino- and Carboxyterminal Residues in the Active Site of the Histidine-Containing Protein HPr of the Phosphoenolpyruvate-Dependent Phosphotransferase System of Staphylococcus Carnosus : Site-Directed Mutagenesis with the ptsH-gene, Biochemical Characterization and NMR Studies of the Mutant Proteins. Prot.Engin . 6 , 417-423.

53. Kienzle, N., Freund, J., Kalbitzer, H. R. & Müller-Lantzsch, N. (1993) Oligomerization of the Nef Protein from Human Immunodeficiency Virus (HIV) Type I. Eur.J.Biochem. 214 , 451-457.

54. Franken, S.M., Scheidig, A.J., Krengel, U., Rensland, H., Lautwein, A., Geyer, M., Scheffzek, K., Goody, R.S., Kalbitzer, H. R., Pai, E.F., & Wittinghofer, A. (1993) Three-Dimensional Structures and Properties of a Transforming and a Nontransforming Gly-12 Mutant of p21 H-ras . Biochemistry 32 , 8411-8420.

B55. Polish translation (1993) of Hausser, K. H. & Kalbitzer, H. R. NMR in Medicine and Biology. Structure Determination, Tomography, In Vivo Spectroscopy. Wydawnictwo Naukowe UAM, Poznan .

B56. Kalbitzer, H.R. (1994) Computer-Aided Analysis of Multidimensional NMR Spectra. In "Two-dimensional NMR-Spectroscopy: Applications for Chemists and Biochemists" (W.R.Croasmun und R.Carlson, eds) pp 581-618, Verlag Chemie, Weinheim.

B57. Russische Übersetzung (1994) von Hausser, K. H. & Kalbitzer, H. R. NMR in Medicine and Biology. Structure Determination, Tomography, In Vivo Spectroscopy. Naukova Dumka, Kiev .

58. Hoffmann, R., Reichert, I. , Wachs, W.O., Zeppezauer, M. & Kalbitzer, H. R. (1994) 1 H and 31 P NMR Spectroscopy of Phosphorylated Model Peptides. Int. J. Pept. Prot. Res . 44 , 193-198.

59. Freund, J., Kellner, M. & Kalbitzer, H. R. (1994) Stability and Proteolytic Domains of Nef Protein from Human Immunodeficiency Virus (HIV) Type 1. Eur.J.Biochem. 221 , 811-819.

60. Slósarek, G., Heintz, D. & Kalbitzer, H. R. (1994) Mobile Segments in Rabbit Skeletal Muscle F- Actin Detected by 1 H Nuclear Magnetic Resonance Spectroscopy. FEBS Lett . 351 , 405-410.

61. Beneicke, W. & Kalbitzer, H. R. (1994) Data Filling in Two-Dimensional NMR Spectroscopy. J. Magn. Reson. A107 , 134-140.

62. Freund, J., Kellner, R., Kovalinka, J., Wolber, W., Kräußlich, H.-G. & Kalbitzer, H. R. (1994) A Possible Regulation of Negative Factor (Nef) Activity of Human Immunodeficiency Virus Type 1 by the Viral Protease. Eur.J.Biochem. 223 , 589-593.

63. Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, H. R., & Wittinghofer, A. (1995) Substrate-Assisted Catalysis as a Mechanism for GTP Hydrolysis of p21 ras and Other Binding Proteins. Nature Struct. Biol. 2 , 36-44 .

64. Geyer, M., Neidig, K.-P. & Kalbitzer, H. R. (1995) Automated Peak Integration in Multidimensional NMR Spectra by an Optimized Iterative Segmentation Procedure. J.Magn.Reson.B 109 , 31-38.

65. Hoffmann, R., Wachs, W.O., Berger, R.G., Kalbitzer, H. R. , Waidelich, D. Baier, E. & Zeppezauer, M.(1995) Chemical Phosphorylation of the Peptides GGXA (X=S; T; Y): an Evaluation of Different Chemical Approaches. Int. J.Pepide Protein. Res. 45 , 26-34.

66. Neidig, K.-P., Geyer, M., Görler, A., Antz, C., Saffrich, R., Beneicke, W., & Kalbitzer, H. R. (1995) AURELIA, a Program for Computer-Aided Analysis of Multidimensional NMR Spectra. J. Biomol. NMR. 6 , 255-270.

67. Freund, J., Vértesy, L., Koller, K.-P., Wolber, W., Heintz, D. & Kalbitzer, H. R. (1995) Complete 1 H Nuclear Magnetic Resonance Assignments and Structural Characterization of a Fusion Protein of the a -Amylase Inhibitor Tendamistat with the Activation Domain of the Human Immunodeficiency Virus Type 1 Tat Protein. J. Mol. Biol . 250 , 672-688.

68. Freund, J. & Kalbitzer, H. R. (1995) Physiological Buffers for NMR Spectroscopy. J. Biomol. NMR. 5 , 321-322.

69. Antz, C., Neidig, K.-P. & Kalbitzer, H. R. (1995) A General Bayesian Method for an Automated Signal Class Recognition in 2D NMR Spectra Combined with a Multivariate Discriminant Analysis. J. Biomol. NMR. 5 , 287-296.

70. Pogge von Strandmann, R., Weigt, C., Fischer, R., Meyer, H.E., Kalbitzer, H. R. & Hengstenberg, W. (1995) Expression, Purification, and Characterization of the Enzyme IIB Mannitol-Specific Domain from Staphylococcus carnosus and Determination of the Active Site Cysteine. Eur. J. Biochem. 233 , 116-122.

71. Slósarek, G., Kalbitzer, H. R. , Mucha, P., Rekowski, P., Kupryszewski, G., Giel-Pietraszuk, M., Szymanski, M. & Barciszewski, J. (1995) Mechanism of the Activation of Proteinase Inhibitor Systesis by Systemin involves b -Sheet Structure, a Specific DNA-Binding Protein Domain. J. Struct. Biol. 115 , 30-36.

72. Rohr, G., Eggert-Kruse, W. & Kalbitzer, H. R. (1995) NMR Spectroscopy in Andrology: Research Aspects and Possible Clinical Applications. Int. J. Androl. 18 , 12-19.

73. Hoffmann, R., Tholey, A., Hoffmann, T., & Kalbitzer, H. R. (1996) Solid-Phase Synthesis of H- and Methylphosphonopeptides. Int. J. Peptide Protein. Res. 47 , 245-253.

74. Raditsch, M., Geyer, M., Kalbitzer, H. R., Jahn, W., Ruppersberg, P., & Witzemann, V. (1996) Polyamine Spider Toxins and Mammalian N-methyl-D-aspartate Receptors. Structural Basis for Channel Blocking and Binding of Argiotoxin 636 . Eur.J.Biochem. 240 , 416-426 .

75. Geyer, M., Schweins, T., Herrmann, C., Prisner, T., Wittinghofer, A., & Kalbitzer, H. R. (1996) Conformational Transitions in p21 H-ras and in its Complexes with the Effector Protein Raf-RBD and the GTPase Activating Protein GAP. Biochemistry 35 , 10308-10302.

76. Schorr, J., Kellner, R., Fackler, O., Freund, J., Kovalinka, J., Kienzle, N., Kräuslich, H.-G., Müller-Lantzsch, N. & Kalbitzer, H. R. (1996) Specific Cleavage Sites of Nef-Protein from Human Immunodeficiency Virus Types 1 and 2 for the Viral Proteases. J.Virology 70 , 9051-9054.

77. Welker, R., Kottler, H., Kalbitzer, H. R. & Kräusslich,H.-G. (1996) Human Immunodeficiency Virus Type 1 Nef Protein is Incorporated into Virus Particles and Specifically Cleaved by the Viral Proteinase. Virology 219 , 228-236.

78. Schweins,T., Geyer, M., Kalbitzer, H. R. , Wittinghofer, A., & Warshel, A. (1996) Linear Free Energy Relationships in the Intrinsic and GTPase Activating Protein-Stimulated Guanosine 5'-Triphosphate Hydrolysis of p21 ras . Biochemistry 35 , 14225-14231.

79. Heintz, D., Kany, H., & Kalbitzer, H. R. (1996) Mobility of the N-Terminal Segment of Rabbit Skeletal Muscle F-Actin Detected by 1 H and 19 F Nuclear Magnetic Resonance Spectroscopy. Biochemistry 35 , 12686-12693.

80. Lisse, T., Bartels, D., Kalbitzer, H. R. & Jaenicke, R. (1996) The Recombinant Dehydrin-Like Desication Protein from the Resurrection Plant Craterostigma plantagineum Displays no Defined Three-Dimensional Structure in its Native State . Biol. Chem. 377 , 555-561.

81. Maurer, T., & Kalbitzer, H. R. (1996) Indirect Referencing of 31 P and 19 F NMR Spectra. J. Magn. Reson. B 113 , 177-178.

82. Görler, A. & Kalbitzer, H. R. (1997) RELAX: A Flexible Program for the Analysis of NOESY-Spectra by Backcalculation Based on the Complete Relaxation Matrix Formalism. J.Magn.Reson. 124 , 177-188.

83. Hoffmann, R., Hoffmann, T., Tholey, A., Schulte, A. C. & Kalbitzer, H. R. (1997) Synthesis and NMR-Spectroscopy of Peptides Containing either Phosphorylated or Phosphonylated cis- or trans-4-hydroxy-L-proline. J. Peptide Res. 49 , 163-173.

84. Nordhoff, A., Tziatzios, C., van den Brock, J. A., Schott, M., Kalbitzer, H. R. , Becker, K., Schubert, D., Schirmer, R. H. (1997) Unfolding and Reactivation of Dimeric Human Glutathione Reductase. An Assay for Folding Inhibitors. Eur. J. Biochem. 245 , 273-282.

85. Antz, C., Geyer, M., Fakler, B., Schott, M. K., Frank, R., Guy, H. R, Ruppersberg, J. P. & Kalbitzer, H. R. (1997) NMR-Structure of Inactivation Gates of Mammalian Voltage-Dependent Potassium Channels. Nature 385 , 272-275.

86. Geyer, M., Herrmann, C., Wohlgemuth, S., Wittinghofer, A., & Kalbitzer, H. R. (1997) Structure of the Ras-Binding Domain of the RalGEF and Implications for Ras Binding and Signalling. Nature Struct. Biol. 4 , 684-698.

87. Schulte, A. C., Görler, A., Antz, C., Neidig, K.-P. & Kalbitzer, H. R. (1997) Use of Global Symmetries in Automated Signal Class Recognition by a Bayesian Method. J. Magn. Reson. 129 , 165-172.

88. Hahmann, M., Maurer, T., Lorenz, M., Glaser, W., Hengstenberg, W. & Kalbitzer, H. R. (1998) Structural Studies of the Histidine-Containing Phosphocarrier Protein (HPr) from Enterococcus faecalis. Eur. J. Biochem. 252 , 51-58.

•  Schott, M., Antz, C., Frank, R., Ruppersberg, J. P. & Kalbitzer, H. R. (1998)

Structure of the Inactivating Gate from the Shaker Voltage Gated K + Channel analyzed by NMR Spectroscopy. Eur. Biophys. J. 27 , 99-104.

90. Görler, A., Gronwald, W., Neidig, K.-P. & Kalbitzer, H. R. (1999) Computer

Assisted Assignment of 13 C or 15 N edited 3D-NOESY-HSQC Spectra Using Back Calculated and Experimental Spectra. J. Magn. Reson. 137 , 39-45.

91. Kalbitzer, H.R. (1999) Biochemie in "Medizinische Physik, Band 1: Grundlagen" (Bille und Schlegel, eds) pp 187-234, Springer Verlag, Heidelberg.

92. Wissmann, R., Baukowitz, T., Kalbacher, H., Kalbitzer, H. R . , Ruppersberg, J. P., Pongs, O., Antz, C. & Fakler, B. (1999) NMR-Structure and Functional Characteristics of the Hydrophilic N-Terminus of the Potassium Channel b -Subunit Kv b 1.1. J. Biol. Chem. 274 , 35521-35525.

93. Linnemann, B. K, Geyer, M., Jaitner, T., Block, C., Kalbitzer, H. R., Wittinghofer, A. & Herrmann, C. (1999) Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF-6 and Members of the Ras Subfamily. J. Biol. Chem. 274 , 13556-13562.

94. Geyer, M., Munte, C. E., Schorr, J., Kellner, R., & Kalbitzer, H. R. (1999) Structure of the Anchor-Domain of Myristoylated and Non-Myristoylated HIV-1 Nef Protein. J. Mol. Biol. 289 , 123-138.

95. Döker, R., Maurer, T., Kremer, W., Neidig, K.-P. & Kalbitzer, H. R. (1999) Determination of Mean and Standard Deviation of Dihedral Angles. Biochem. Biophys. Res. Comm. 257 , 348-350.

96. Antz, C., Bauer, T., Kalbacher, H., Frank, R., Covarrubias, M., Kalbitzer, H. R. , Ruppersberg, J. P., Baukrowitz, T. & Fakler, B. (1999) Control of K + Channel Gating by Protein Phosphorylation: Structural Switches of the Inactivation Gate. Nature Struct. Biol. 6 , 146-150.

97. Vetter, I., Linnemann, T., Wohlgemuth, S., Geyer, M., Kalbitzer, H. R., Herrmann, C. & Wittinghofer, A. (1999) Structural and Biochemical Analysis of Ras-Effector Signaling via RalGEF. FEBS Lett. 451 , 175-180.

98. Geyer, M., Assheuer, R., Klebe, C., Kuhlmann, J., Becker, J., Wittinghofer, A. & Kalbitzer, H. R. (1999) Conformational States of the Nuclear GTP-binding Protein Ran and its Complexes with the Exchange Factor RCC1 and the Effector Protein RanBP1. Biochemistry 38 , 11250-11260.

99. Praefcke, G. J. K., Geyer, M., Schwemmle, M., Kalbitzer, H. R. & Herrmann, C. (1999) Nucleotide Binding Characteristics of Human Guanylate-Binding Protein 1 (hGBP1) and Identification of the Third GTP-Binding Motif. J. Mol. Biol. 292 , 321-332.

100. Lee, B.-S., Maurer, T., Kalbitzer, H. R. & Holler, E. (1999) b -poly(L-malate) Production by Physarum polycephalum. 13 C Nuclear Magnetic Resonance Studies. Appl. Microbiol. Biotechnol. 52 , 415-420.

101. Görler, A., Hengstenberg, W., Kravanja, M., Beneicke, W,. Maurer, T. & Kalbitzer, H. R. (1999) Solution Structure of Histidine Containing Phosphocarrier Protein (HPr) from Staphylococcus carnosus . Appl. Magn. Reson. 17 , 465-480.

102. Kalbitzer, H. R. , Görler, A., Li, H., Dubovskii, P., Hengstenberg, W., Kowolik, C., Yamada, H., & Akasaka, K. (2000) 15 N and 1 H NMR Study of Histidine Containing Protein (HPr) from Staphylococcus carnosus at High Pressure. Prot. Sci. 9 , 693-703.

103. Huber, F., Gronwald, W., Wohlgemuth, S., Herrmann, C., Geyer, M., Wittinghofer, A. & Kalbitzer, H. R. (2000) Sequential NMR assignments of the RAS-binding domain of Byr2. J. Biomol. NMR 16 , 355-356.

104. Inouhe, K., Yamada, H., Akasaka, K., Herrmann, C., Kremer, W., Maurer, T., Döker, R. & Kalbitzer, H. R. (2000) Pressure-induced local unfolding of the Ras binding domain of RalGDS. Nature Struct. Biol. 7 , 547-550.

105. Brunner, E., Weitzel, J., Heitmann, B., Maurer, T., Strätling, W. H. & Kalbitzer, H. R (2000) Sequence-specific 1 H, 13 C, and 15 N assignments of the MAR-binding domain of chicken MeCP2/ARBP . J. Biomol. NMR 17 , 175-176.

106. Brunner, E. Ogle, J., Wenzler, M. & Kalbitzer, H. R. (2000) Molecular alignment of proteins in bicellar solutions: quantitative evaluation of effects induced in 2D COSY spectra. Biochem. Biophys. Res. Comm. 272 , 694-698.

107. Gronwald, W., Kirchhöfer, R. Görler, A., Kremer, W., Ganslmeier, B., Neidig, K.-P. & Kalbitzer, H. R. (2000) RFAC, a programm for automated NMR-R-factor estimation. J. Biomol. NMR 17 , 137-151.

108. Steiner, G., Kremer, W., Linnemann, T., Herrmann, C., Geyer, M. and Kalbitzer, H. R. (2000) Sequence-specific resonance assignments of the Ras-binding domain of AF6. J. Biomol. NMR 18 , 73-74.

109. Maurer, T., Döker, R., Görler, A., Hengstenberg, W. & Kalbitzer, H. R. (2001) Three-dimensional structure of the histidine containing phopsphocarrier protein (HPr) from Enterococcus faecalis in solution. Eur. J. Biochem. 268 , 635-644.

110. Rohrer, M., Prisner, T. F., Brügmann, O., Käß, H., Spoerner, M., Wittinghofer, A. & Kalbitzer, H. R. (2001) Structure of the metal-water complex in Ras.GDP studied by high-field EPR spectroscopy and 31 P NMR spectroscopy. Biochemistry 40 , 1884-1889.

111. Kremer, W., Schuler, B., Harrieder, S., Geyer, M., Gronwald, W., Welker, C., Jaenicke, R & Kalbitzer, H. R. (2001) Solution NMR structure of the cold-shock protein from the hyperthermophilic bacterium Thermotoga maritima . Eur. J. Biochem . 268 , 2527-2539.

112. Riepl, H., Scharf, B., Schmitt, R., Kalbitzer, H. R. & Maurer, T. (2001) Sequential Assignment and Secondary Structure of the 14 kDa chemotactic Protein CheY2 from Sinorhizobium meliloti. J. Biomol. NMR 19 , 287-288.

113. Gronwald, W., Brunner, E., Huber, F., Wenzler, M., Herrmann, C.,. & Kalbitzer, H. R. (2001) Overcoming the problems associated with poor spectra quality of protein kinase Byr2 using residual dipole couplings. Prot. Sci . 10 , 1260-1263.

114. Wenzler, M., Brunner, E., Kröger, N., Lehmann, G., Sumper, M. & Kalbitzer, H. R. (2001) 1 H, 13 C and 15 N sequence-specific resonance assignment of the PSCD4 domain of diatom cell wall protein pleuralin-1. J. Biomol. NMR 20 , 191-192.

115. Spoerner, M., Herrmann, C., Vetter, I. R., Kalbitzer, H. R. & Wittinghofer, A. (2001) Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc. Natl. Acad. Sci. USA 98 , 4944-4949.

116. Inoue, K., Maurer,T., Yamada, H., Herrmann, C., Horn, G., Kalbitzer, H. R . & and Akasaka, K. (2001) High-pressure NMR study of the complex of a GTPase Rap1A with its effector RalGDS. A conformational switch in RalGDS revealed from non-linear pressure shifts. FEBS Lett. 506 , 180-184.

117. Brunner, E., Arnold, M. R., Kremer, W. & Kalbitzer, H. R. (2001) Pressure stability of phospholipid bicelles: measurements of residual dipolar couplings under extreme conditions. J. Biomol. NMR 21 , 173-176..

B118. Akasaka, K., Li, H., Dubovskii, P., Kalbitzer, H. R. & Yamada, H. (2001) High Resolution High-Pressure NMR Spectroscopy - Application to Protein Structure, Dynamics and Folding. In 'Dynamics, Structure and Function of Biological Macromocules´ (O. Jardetzky and M. D. Finucane, eds) IOS press, Amsterdam , Nato Science Series A 315 , 77-92.

119. Maurer, T., Bomke, J., Frech, M., Rysiok, T. & Kalbitzer, H. R. (2001) Sequential assignment and secondary structure of Saratin, an inhibitor of von Willebrand factor dependent platelet adhesion to collagen. J. Biomol. NMR 21 , 77-78 .

120. Kremer, W. & Kalbitzer, H. R . (2001) Physiological conditions and practicality for protein nuclear magnetic resonance spectroscopy : Experimental methodologies and theoretical background. Meth. Enzymol . 339 , 3-19.

121. Gronwald, W., Huber, F., Grünewald, P., Spörner, M., Wohlgemuth, S., Herrmann, C., & Kalbitzer, H. R. (2001) Solution Structure of the Ras-binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe. Structure 9 , 1029-1041.

122. Sahrbacher, U., Pehlke-Rimpf, A., Rohr, G., Eggert-Kruse, W. & Kalbitzer, H. R. (2002) High Resolution Proton Magnetic Resonance Spectroscopy of Human Cervical Mucus. J. Pharm. Biomed. Anal. 28 , 872-840.

B123. Horn, G., Maurer, T. & Kalbitzer, H. R . (2002) The small GTPase Ral. In „ Encyclopedia of Molecular Medicine “ (T. E. Creighton, ed), Vol. 5, pp 2722- 2726, John-Wiley and Sons, New York., 2002.

124. Arnold, M.R., Kremer, W., Luedemann, H.-D. & Kalbitzer, H. R . (2002) 1 H NMR parameters of common amino acid residues measured in aqueous solutions of the linear tetrapeptides Gly-Gly-X-Ala at pressures between 0.1 and 200 MPa. Biophys. Chem. 96 , 129-140.

125. Kalbitzer, H. R. & Petrides (2002) Kap. 3 Proteine (Polyaminosäuren). In: „Biochemie und Pathobiochemie“ (L. Löffler & Petrides, eds), pp 57-102, 7 th edition, Springer Verlag, Heidelberg.

126. Döker, R., Zhao, X., Kremer, W., Braslavsky, C. V., Kuhlmann, J. & Kalbitzer, H. R. Sequence-specific resonance assignment of the second Ran-binding domain of human RanBP2. J. Biomol. NMR 22 , 185-186.

127. Stumber, M., Herrmann, H., Wohlgemuth, S., Kalbitzer, H. R ., Jahn, W. & Geyer, M. (2002) Synthesis, characterization and application of two nucleoside triphosphate analogues, GTP g NH 2 and GTP g F. Eur. J. Biochem. 269 , 3270-3278.

128. Kany, H., Wolf, J. & Kalbitzer, H. R . (2002) Myosin II from rabbit skeletal muscle and D ictyostelium discoideum and its interaction with F-actin studied by 1 H NMR spectroscopy. FEBS Lett . 521 , 121-126.

129. Gronwald, W., Moussa, S., Elsner, R., Jung, A., Ganslmeier, B., Trenner, J., Kremer, W., Neidig, K.-P., & Kalbitzer, H. R. (2002) Automated assignment of NOESY NMR spectra using a knowledge based method (KNOWNOE). J. Biomol. NMR 23 , 271-287.

130. Schuler, B., Kremer, W., Kalbitzer, H. R. & Jaenicke, R. (2002) Role of entropy in protein thermostability: Folding kinetics of a hyperthermophilic cold schock protein at high temperatures using 19 F-NMR. Biochemistry 41 , 11670-11680.

131  Stumber, M., Geyer, M., Graf, R., Kalbitzer, H. R ., Scheffzek, K. & Haeberlen, U. (2002) Observation of slow dynamic exchange processes in Ras protein crystals by 31 P solid state NMR spectroscopy, J. Mol. Biol. 323, 899-907.

B132. Kremer, W., Arnold, M. R., Brunner, E., Schuler, B., Jaenicke, R. & Kalbitzer, H. R. (2003) High pressure NMR spectroscopy and its application to the cold shock protein Tm Csp from the hyperthermophilic bacterium Thermotoga maritima . In “Advances in high pressure bioscience and biotechnology II”. (R. Winter, ed.), pp 101-112. Springer, Berlin .

133. Wissmann, R., Bidl, W., Oliver D., Beyermann, M., Kalbitzer, H. R. , Bentrop, D. & Fakler, B. (2003) Solution structure of the ‘tandem-inactivation domain' of the neuronal A-type potassium channel Kv1.4. J. Biol. Chem . 278 , 16142-16150.

134. Arnold, M. R. Kalbitzer, H. R . & and Werner Kremer, W. (2003) High-sensitivity sapphire cells for high pressure NMR spectroscopy on proteins. J. Magn. Reson . 61 , 127-131.

135. Kremer, W. & Kalbitzer, H. R. (2003) Hochdruck-NMR-Spektroskopie an Proteinen. Biospektrum 2 , 142-145.

136. Gröger, C., Möglich, A., Pons, M., Koch, B., Hengstenberg, W., Kalbitzer, H. R. , & Brunner, E. (2003) NMR-spectroscopic mapping of an engineered cavity in HPr the I14A Mutant from S. carnosus using xenon. J. Am. Chem. Soc . 125 , 8726-8727.

137. Heitmann, B., Maurer, T., Weitzel, J. M., Strätling, W. H., Kalbitzer, H. R . & Brunner, E. (2003) S olution structure of the matrix attachment region-binding domain of chicken MeCP2 . Eur. J. Biochem. 27 0, 3236-3270.

138. Kachel, N., Erdmann, K. S., Kremer, W., Wolff, P., Gronwald, W., Heumann, R Kalbitzer, H. R. (2003) Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): Splicing induced modulation of ligand specificity. J. Mol. Biol . 334 , 143-155.

139. Geyer, M., Wilde, C., Selzer, J., Aktories, K., and Kalbitzer, H. R. (2003) Glucosylation of Ras by Clostridium sordellii lethal toxin: Consequences for the effector loop conformations observed by NMR spectroscopy. Biochemistry 42 , 11951-11959.

140. Stadlhanner, K., Theis, F. J., Lang, E. W., Gronwald, W., Kalbitzer, H. R . (2003) A matrix pencil approach to the blind source separation of artifacts in 2D NMR spectra. Neur. Inform. Process. 1, 103-110 .

141. Ellenrieder, A.-D., Kremer, W., Kattenbeck, B., Hantschel, O., Horn, G., Kalbitzer, H. R . & Modrow, S. (2004) The central domain of the matrix protein from HIV-1: Influence on protein structure and virus infectivity. Biol. Chem . 385 , 303-313.

142. Gronwald, W. and Kalbitzer, H. R. (2004) Automated Structure Determination of Proteins by NMR Spectroscopy. Progr. NMR Spectr. 44 , 33-96.

143. Jung, A., Bamann, C., Kremer, W., Kalbitzer, H. R. & Brunner, E. (2004) High-temperature solution NMR structure of Tm Csp. Prot. Sci. 13 , 342-350.

144. Kremer, W., Steiner, G., Béraud-Dufour, S., & Kalbitzer, H. R. (2004) Conformational

states of the small G protein Arf-1 in complex with the guanine nucleotide exchange factor ARNO-Sec7. J. Biol. Chem . 279 , 17004-17012.

145. Riepl, H., Scharf, B., Schmitt, R., Kalbitzer, H. R. & Maurer, T. (2004) Solution structures of the inactive and BeF 3 -activated response regulator CheY2. J. Mol. Biol . 338 , 287-297.

146. Maurer, T., Meier, S., Kachel, K., Munte, C. E., Hasenbein, S., Koch, B., Hengstenberg, W. & Kalbitzer, H. R. (2004) High Resolution Structure of the Histidine Containing Phosphocarrier Protein (HPr) from Staphylococcus aureus and Characterisation of its Interaction with the bifunctional HPrKinase/Phosphorylase. J. Bacteriol . 186 , 5906-5918.

147. Gronwald, W., Brunner, K., Kirchhöfer, R., Nasser, A., Trenner, J., Ganslmeier, B., Riepl, H., Ried, A., Schreiber, J., Elsner, R., Kalbitzer, H. R. & Neidig, K.-P. (2004) The new AUREMOL program. Automation of protein structure elucidation. Bruker Report 154/155 , 11-14.

148. Ried, A., Gronwald, W., Trenner, J. M., Brunner, K., Neidig, K.-P. & Kalbitzer, H. R. (2004) Improved simulation of NOESY spectra by RELAX-JT2 including effects of J-coupling, transverse relaxation, and chemical shift anisotropy. J. Biomol. NMR 30 , 121-131.

149. Canalia, M., Malliavin, T. E., Kremer, K., & Kalbitzer, H. R . (2004) Molecular dynamics simulations of HPr under hydrostatic pressure. Biopolymers 74 , 377-388, Erratum: Biopolymers 74, 495.

150. Kremer, W., Arnold, M. R., Kachel, N. & Kalbitzer, H. R. (2004) The use of high- sensitivity sapphire cells in high pressure NMR spectroscopy and its application to proteins. Spectroscopy 18 , 271-278.

151. Iuga, A., Spoerner, M., Kalbitzer, H. R. & Brunner, E. (2004) Solid-state 31 P NMR spectroscopy of microcrystals of the Ras protein and its effector loop mutants: Comparison of solution and crystal structures. J. Mol. Biol. 342 , 1033-1040.

152. Hattori, M., Li, H., Yamada, H., Akasaka, K., Hengstenberg, W., Gronwald, W. & Kalbitzer, H. R. (2004) Infrequent cavity-forming fluctuations in HPr from Staphylococcus carnosus revealed by pressure and temperature-dependent tyrosine ring-flips. Prot. Sci. 13 , 3104-3114.

153. Möglich, A., Koch, B., Gronwald, W., Hengstenberg,, W., Brunner, E. & Kalbitzer, H. R. (2004) Solution structure of the active-centre mutant Ile14Ala of the histidine-containing phosphocarrier protein (HPr) from Staphylococcus carnosus. Eur. J. Biochem. 271 , 4815-4824.

154. Spoerner, M., Wittinghofer, A. & Kalbitzer, H.R. (2004) Perturbation of the conformational equilibria of the effector loop of Ras by selective mutations studied by 31 P NMR spectroscopy. FEBS Lett . 578 , 305-310 . .

155. Möglich, A., Weinfurtner, D., Gronwald, W., Maurer, T. & Kalbitzer, H. R. (2005) PERMOL: Restraint-based protein homolo gy modeling using DYANA or CNS. Bioinform. 21 , 2110-2111.

156. Spoerner, M., Nuehs, A., Ganser, P., Herrmann, C., Wittinghofer, A. & Kalbitzer, H.R. (2005) Conformational states of Ras complexed with the GTP-analogs GppNHp or GppCH 2 p: implications for the interaction with effector proteins. Biochemistry 44 , 2225-2236.

157. Möglich, A., Weinfurtner, D., Maurer, T., Gronwald, W. & Kalbitzer, H. R. (2005) A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles. BMC Bioinform . 6 :91.

158. Geyer, J. P., Döker, R., Kremer, W., Zhao, X., Kuhlmann, J. & Kalbitzer, H. R. (2005) Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran. J. Mol. Biol. 348 , 711-725.

159. Riepl, H., Hartl, R. ,Bauer, M., Nar, H., Kauschke, S. G., Kalbitzer, H. R. & and Maurer, T. (2005) Sequential Backbone Assignment of Peroxisome Proliferator-Activated Receptor g Ligand Binding Domain. J. Biomol. NMR. 32 , 259-259.

166. Nisius, L., Stadler, M., Kalbitzer, H. R. & Brunner, E. (2005) NMR-Spectroscopic Study of Noble Gas-binding into the Engineered Cavity of HPr(I14A) from Staphylococcus carnosus. J. Chem. Phys. 109 , 17795-17798.

161. Munte, C. E., Vilela, L., Kalbitzer, H. R. & Garratt, R. C. (2005) Solution Structure of Human Proinsulin C-Peptide. FEBS J. 272 , 4284-4293.

162. Munte, C. E., Becker, K., Schirmer, R. H. & Kalbitzer, H. R. (2005) 1 H, 13 C, and 15 N sequence-specific resonance assignme nt and secondary structure of Plasmodium falciparum thioredoxin . J. Biomol. NMR 32 , 340-340.

163. Hofweber, R., Horn, G., Langmann, T., Balbach, J., Kremer, W., Schmitz, G. & Kalbitzer, H. R. (2005) The influence of cold shock proteins on transcription and translation studied in cell-free model systems. FEBS J . 272 , 4691-4702.

164. Spoerner, M., Graf, T., König, B. & Kalbitzer, H.R. (2005) A Novel Mechanism for the Modulation of the Ras-Effector Interaction by small molecules. Biochem. Biophys. Res. Comm. 334 , 709-713.

165. Spoerner, M., Prisner, T. F. , Bennati, M., Hertel, M., Weiden, N., Schweins, T. & Kalbitzer, H.R. (2005) Conformational States of Human H -Ras Detected by High-Field EPR, ENDOR, and 31 P NMR Spectroscopy. Magn. Reson. Chem . 43 , S74-S83.

166. Böhm, M., Stadlthanner, K., Gruber, P., Theis, F. J., Lang, E. W., Tomé, A. M., Teixeira, A. R., Gronwald, W. & Kalbitzer, H. R. (2006) On the use of simulated annealing to automatically assign decorrelated components in second-order blind source separation. IEEE Transact. Biomed. Engineer . 53 , 810-820.

167. Bennati, M., Hertel, M. M., Fritscher, J., Prisner, T. F., Weiden, N., Hofweber, R., Spoerner, M., Horn, G., & Kalbitzer, H.R. (2006) High-frequency 95 GHz ENDOR Characterization of the Metal Binding Sites in Wild Type Ras.GDP and its Oncogenic Mutant G12V in Frozen Solution. Biochemistry 45 , 42-45.

168. Stadlthanner, K., Tomé, A. M., Theis, F. J., Lang, E. W., Gronwald, W. & Kalbitzer, H. R. (2006) Separation of water artefacts in 2D NOESY protein spectra using congruent matrix pencils. Neurocomp. 96 , 497-522.

169. Ab, E., Atkinson, A. R., Banci, L., Bertini, I., Ciofi-Baffoni, S., Brunner, K., Diercks, T., Dötsch, V., Engelke, F., Folkers, G. E., Griesinger, C., Gronwald, W., Günther, U., Habeck, M., de Jong, R., N., Kalbitzer, H. R. , Kieffer, B., Leeflang, B. R., Loss, S., Luchinat, C., Marquardsen, T., Moskau, D., Neidig, K.-P., Nilges, M., Piccioli, M., Pierattelli, R., Rieping, W., Schippmann, T., Schwalbe, H., Travé, G., Trenner, J., Wöhnert, J., Zweckstetter, M. and Kaptein, R. (2006) NMR in the SPINE Structural Genomics project. A. Cryst. D62 , 1150-1161.

170. Iuga, A., Spoerner, M., Ader, A., Brunner, E. and Kalbitzer, H. R. (2006) Rapid assignment of solution 31 P NMR spectra of large proteins by solid-state spectroscopy. Biochem. Biophys. Res. Comm. 346 , 301-305.

171. Brunner, K., Gronwald, W., Trenner, J. M., Neidig, K.-P. & Kalbitzer, H. R. (2006) A General Method for the Unbiased Improvement of Solution NMR Structures by the Use of Related X-Ray Data, the AUREMOL-ISIC Algorithm. BMC Struct. Biol. 346 , 301-305.

172. Kachel, N., Kremer, W., Zahn, R. & Kalbitzer, H. R. (2006) Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy. BMC Struct. Biol. 16 , 6.

B173. Kalbitzer, H. R. & Petrides, P. E. (2007) Kap. 3 Proteine . In: „Biochemie und Pathobiochemie“ (L. Löffler, Petrides, & Heinrich, eds), pp. 55 to 98, 8 th edition, Springer Verlag, Heidelberg, in press.

174. Gronwald, W., Brunner, K., Kirchhöfer, R., Trenner, J., Neidig, K.-P. & Kalbitzer, H. R . (2007) AUREMOL-RFAC-2D, combination of R-factors and their use for automated quality assessment of protein structures. J. Biomol. NMR 37 , 15-30.

B175. Kalbitzer, H. R., Kremer, W., Schumann, F., Spörner, M.. & Gronwald, W. (2007) Kap. 7 Elucidation of protein-protein and protein-ligand interactions by NMR spectroscopy. In Protein Reviews, Vol. 5, “ Protein interactions - Biophysical approaches for the study of complex reversible systems” (Peter Schuck, ed.), pp 189 to 230, Springer Verlag Heidelberg.

176. Spoerner, M., Nuehs, A., Herrmann, C., Steiner, G. & Kalbitzer, H. R. (2007) Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTP g S . FEBS J . 274 , 1419-1433..

177. Ader, A., Spoerner, M., Kalbitzer, H. R. & Brunner, E.. (2007) Solid-State 31 P NMR Spectroscopy of precipitated guanine nucleotide-binding protein Ras in complexes with its effector molecules Raf kinase and RalGDS. J. Phys. Chem., in press.

B178. Horn, G., Hofweber, R., Kremer, W. & Kalbitzer, H. R. (2007) Structure and function of bacterial cold shock proteins. Cell. Mol. Life Sci Cell. Mol. Life Sci. 64, 1457 – 1470.

179. Schumann, F. H., Riepl, H., Maurer, T., Gronwald, W., Neidig, K.-P., & Kalbitzer, H. R . (2007) Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions. J. Biomol. NMR 39 , 275–289 .

180. Kremer, W., Kachel, N., Kuwata, K., Akasaka, K., & Kalbitzer, H. R. (2007) Species specific differences in the intermediate states of human and Syrian hamster prion protein detected by high pressure NMR spectroscopy. J. Biol. Chem. 282 , 22689–22698,

181. Rudolph, C., Sigruener, A., Hartmann, A., Bals-Pratsch, M., Gronwald, W, Seifert, B., Kalbitzer, H. R., Verdorfer, I., Luetjens, C. M., Ortmann, O., Bornstein, S. R. & Schmitz , G. (2007) ApoA-I Binding Protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis, Horm. Metab. Res . 39 , 322-335 .

182. Brügger, B., Krautkrämer, E., Tibroni, N., Munte, C. E., Rauch, S., Leibrecht, I., Glass, B., Bräuer, S., Geyer, M., Kräusslich, H.-G., Kalbitzer, H.R ., Wieland, F.T. and Fackler, O.T . (2007) Human Immunodeficiency Virus Type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains. Retrovir. 4 :70, 1-12.

183. Kaess, B., Fischer, M., Baessler, A., Stark, K., Huber, F., Kremer, W., Kalbitzer, H. R ., Schunkert, H., Riegger, G., Hengstenberg, C. (2008) The lipoprotein subfraction profile: heritability and identification of quantitative trait loci . J. Lipid. Res., in press.

184. Munte, C. E., Gäde, G., Domogalla, B., Kremer, W., Kellner, R., & Kalbitzer, H. R. (2008) C-mannosylation in the hypertrehalosaemic hormone (HrTH) from the stick insect Carausius morosus , FEBS J . 275 , 1163-1173.

185. Gronwald, W. Bombke, J., Maurer, T., Domogalla, B., Huber, F., Schumann, F., Kremer, W., Fink, F., Rysiok, T., Frech, M. & Kalbitzer, H. R. (2008) Structure of the Leech Protein Saratin and Characterisation of its Binding to Collagen. J. Mol. Biol . 381 , 913–927.

186. Riepl, H., Maurer, T., Kalbitzer, H. R ., Meier, V. M., Haslbeck, M., Schmitt, R. & Scharf, B. (2008) Interaction of CheY2 and CheY2-P with the cognate CheA kinase in the chemosensory-signalling chain of Sinorhizobium meliloti. Mol. Microbiol. 69 , 1373-1384.

187. Seitz, C., Eberle, W., Kalbitzer, H. R. , & Knoll, M. (2008) Evidence for a cystein proteinase involved in BSE infection and/or progression. Biochemica 3 , 26-27.

188. Sasaki, K., Gaikwad, J., Hashiguchi, S. Kubota, T., Sugimura, K., Kremer, W., Kalbitzer, H. R. and Akasaka, K. (2008) Reversible monomer-oligomer transition in human prion protein. Prion 2, 118-122.

189. Ramm, P., Couillard-Despres, S., Plötz, S., Rivera, F. J., Krampert, M., Lehner, B., Kremer, W., Bogdahn, U., Kalbitzer, H. R. & Aigner, L. (2009) A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis? Stem Cells 27 , 420-423 .

190. Baskaran, K., Kirchhöfer, R., Huber, F., Trenner, J., Brunner, K., Gronwald, W., Neidig, K.-P. and Kalbitzer, H. R. (2009) Chemical Shift Optimization in Multidimensional NMR Spectra by AUREMOL-SHIFTOPT. J. Biomol. NMR 43, 197–210 .

191. Linsel-Nitschke, P., Jansen, H., Aherrarhou, Z., Belz, S., Mayer, B., Huber, F., Kremer, W., Kalbitzer, H. R. , Erdmann J. and Schunkert, H. (2009) Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography. Lipids Health Desease 8 :14.

192. Munte, C. E., Becker, K., Schirmer, R. H., and Kalbitzer, H. R. (2009) NMR assignments of oxidised thioredoxin from Plasmodium falciparum . Biomol. NMR Assignments , in press.

193. Schumann, F., Hoffmeister, H., Bader, R., Schmidt, M., Witzgall, R., & Kalbitzer, H. R . (2009) Ca 2+ -Dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2. J. Biol. Chem. 284 , 24372–24383.

194. Winklmeier, A., Weyand, M., Schreier, C., Kalbitzer, H. R. & Kremer, W. (2009) Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3. A. Crystal. F65 , 688-691.

195. Schreier, C., Auer, A., Kalbitzer, H. R. and Kremer, W. (2009) NMR Assignments of a 48 kDa Tetramer of the T1 Domain of the mammalian Voltage Gated Potassium Channel Kv1.4. Biomol. NMR Assignments , in press.

196. Schumann, F. H., Hoffmeister, H., Schmidt, M., Bader, R., Besl, E., Witzgall, R. and Kalbitzer, H. R. (2009) NMR-Assignments of a Cytosolic Domain of the C-Terminus of Polycystin-2. Biomol. NMR Assignments 3 , 141-144.

197. Kalbitzer, H. R ., Spoerner, M., Ganser, P. and Kremer, W. (2009) A fundamental link between folding and function as studied by high pressure NMR spectroscopy of the Ras protein. J. Am. Chem. Soc. , in press.

198. Cano, C., Brunner, K. Elsner, R., Baskaran, K., Munte, C. E. and Kalbitzer, H. R. (2009) Protein structure calculation with data imputation: the use of substitute restraints. J. Biomol. NMR , in press.

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