Herbert Tschochner

1997 - 2003
Group Leader Biochemistry Center Heidelberg (BZH)

1993 - 1997
Research Assistant, University of Heidelberg, Institute for Biochemistry (head F. Wieland)

1989 – 1992
PostDoc with R. Kornberg, Stanford University, School of Medicine

1987 – 1989
Research Assistant, University of Regensburg, Institute for Biochemistry I (head M. Sumper)

1983 – 1987
PhD work, University of Regensburg, Institute for Biochemistry I (supervisor M. Sumper)

Keywords

RNA polymerase I, transcription, initiation, elongation, termination, rRNA processing, ribosome synthesis, export, ribosome maturation, nucleolus, S. cerevisiae

Primary research interest

Ribosomes, the cellular factories for protein production, are among the most intricate and complex Ribonucleoprotein (RNP)-assemblies in the cell. Their biogenesis is tightly regulated and requires the coordinated activity of many cellular processes and can therefore be considered as a well-suited model system to study mechanisms of biogenesis of RNP complexes. Synthesis of the majority of ribosomal RNAs in eukaryotes is executed by a highly specialized RNA polymerase, Pol I. Our major interests are to understand mechanisms and regulation of the RNA polymerase I transcription machinery and to study how rRNA synthesis is coupled to rRNA maturation and assembly of pre-ribosomes.

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