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Short CV
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2006 – present
Academic staff member (group leader) at the University of Regensburg (Germany)
Department of Biochemistry III (Chair: H. Tschochner, Längst laboratory)
Oct.-Dec. 2007, Mai-Jul. and Nov.-Dec. 2008
Visiting Scientist at the LMU Biozentrum (Munich, Germany)Department of Human Genetics (Head: T. Cremer) |
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2006-2012
Habilitation at the NWFIII University of Regensburg (Germany) |
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2002 – 2006
Postdoc at the LMU Adolf-Butenandt-Institut (Munich, Germany)
Department of Molecular Biology (Head: P. B. Becker)
Group: G. Längst |
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1997 – 2002
PhD at the German Cancer Research Center (Heidelberg, Germany) & at the Semmelweis University, Institute of Pathology and Experimental Cancer Research (Budapest, Hungary) (1998 TEMPUS fellow, 1999 DAAD fellow)
Groups: I. Grummt, I. Kovalszky |
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+49 (0)941 9431748 |
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attila.nemeth (at) vkl.uni-regensburg.de
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Keywords |
nucleolus, genomics, nuclear architecture, genome organization, chromatin higher-order structure |
Primary research interest
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The nucleolus is the largest compartment of the cell nucleus. Ribosomal RNAs (rRNAs) are synthesized, processed and assembled with ribosomal proteins in the nucleolus, and these processes involve the activity of all three RNA polymerases. In addition, biological processes, including RNA modification, cell-cycle control, senescence, viral infections and stress sensing, also occur in this compartment. These processes are tightly regulated, highly dynamic and directly influence nucleolar size and compartmentalisation. In addition to rRNA clusters, nucleoli are surrounded with a shell of condensed genomic DNA. Chromatin motion is constrained at the nucleolus, indicating its role in higher-order chromatin arrangement. Therefore, the nucleolus can be considered as a well-suited model system to investigate nuclear architecture dynamics in the interphase nucleus. Our research focuses on the role of the nucleolus in genome organization and function.
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Skills
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Expertise in molecular and cell biology techniques: FISH methods, microscopy imaging, cloning, PCR techniques, reporter assays, in vitro transcription, chromatin analysis, Southern, Northern, Western blot, protein expression in bacteria, insect and mammalian cells. Experience in high-throughput methods (microarrays, massive parallel sequencing, data analysis).
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