Philipp Milkereit

2003 – present
Permanent academic staff member at the Department of Biochemistry III (Chair: Prof. H. Tschochner, University of Regensburg, Germany)

2001 – 2003
Postdoc in the group of Prof. N. Gas (LBME, Toulouse, France)

1999 – 2001
Postdoc in the group of Dr. H. Tschochner (BZH, University of Heidelberg, Germany)

Keywords

Ribosome assembly, RNP maturation, rDNA Transcription

Primary research interest

Ribosomes catalyze the translation of mRNA into proteins. Thereby, they have a key role in gene expression, cell growth and cell cycle progression. Ribosomes are large ribonucleo-protein complexes (RNP’s) consisting  of  ribosomal RNA (rRNA) and a large number (>50) of ribosomal proteins (r-proteins). Recent years brought detailed insights into the 3D-organisation of rRNA and r-proteins in mature ribosomes. In addition, it became evident that a significant proportion of the genome of an unicellular eukaryote (S. cerevisiae) codes for factors which are required for making ribosomes. Taking yeast  ribosome biogenesis as model system, we use a variety of in vivo and in vitro approaches to study the interrelationship between important  processes  common to  eukaryotic RNP maturation pathways, namely RNA synthesis, RNA processing, RNP assembly and intracellular transport of  RNP precursors.

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