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The research at the LAE is funded by the German Research Council (Deutsche Forschungsgemeinschaft) through the Research Unit (Forschergruppe) FOR 1075 “Regulation and pathology of homeostatic systems for visual function”.
Projects:
Genetically
Modified Animal Models for Primary Open-Angle Glaucoma
Primary open-angle glaucoma (POAG) is one of the most frequent causes of blindness worldwide. The project studies the molecular function of genes that have been identified to cause inherited forms of POAG using cell culture systems, anterior segment organ culture perfusion, and by the generation of transgenic animal models.
Principal
Investigator: Ernst Tamm
Team:
Walter Paper, Annika Pienimäki-Römer, Martin Gallenberger, Tina
Schiereis, Loreen März, Kathrin Ebner, Dominik Meinel, Christiane Sippl
Grant
Support: Research Unit (Forschergruppe)
FOR 1075 “Regulation and pathology of homeostatic systems for visual
function”, TP5
Funding period: 1.8.2008 – 31.6.2011
The
Functional Role of Norrin
Norrin, a secreted polypeptide, is the gene product of the NDP-Gene that is modified in Norrie disease. Previous data indicate a role in angiogenesis during fetal development of the retina. The project studies the molecular function of norrin using cell culture systems, anterior segment organ culture perfusion, and by the generation of transgenic animal models.
Principal
Investigators: Ernst Tamm and Andreas
Ohlmann
Team:
Barbara Braunger, Roswitha Seitz, Simon Hackel, Ludwig Zeilbeck
Grant
Support: Research Unit (Forschergruppe)
FOR 1075 “Regulation and pathology of homeostatic systems for visual
function”, TP8, and Pro
The
Functional Role of CTGF, TGF-beta, and BMP-7 for Aqueous Humor Dynamics
and Pathogenesis of Primary Open-Angle Glaucoma
Team:
Benjamin Junglas, Sabrina Ullmann, Tina Schiereis
Grant
Support: Research Unit (Forschergruppe)
FOR 1075 “Regulation and pathology of homeostatic systems for visual
function”, TP3