Publications

Sippl C, Bosserhoff AK, Fischer D, Tamm ER.
Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.
Exp Eye Res. 2011 Aug 27. [Epub ahead of print]

Fuchshofer R., Ullmann S., Zeilbeck L.F., Baumann M., Junglas B., Tamm E.R. (2011) Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury. Histochem Cell Biol., Aug 4. [Epub ahead of print]

Ohlmann A., Merkl R., Tamm E.R. (2011). Focus on Molecules: Norrin. Exp. Eye Res.,Jun 30. (PubMed)

Tamm E.R. (2011). Entwicklung des Kammerwinkels und kongenitales Glaukom [Development of the iridocorneal angle and congenital glaucoma].
Ophthalmologe, 108, 610-617. (PubMed)

Kritzenberger M., Junglas B., Framme C., Helbig H., Gabel V.-P., Fuchshofer R., Tamm E.R., Hillenkamp J. (2011). Different collagen types define two types of idiopathic epiretinal membranes. Histopathology, ;58, 953-965. (PubMed)

Gallenberger M, Meinel DM, Kroeber M, Wegner M, Milkereit P, Boesl MR, Tamm ER.
Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.
Hum Mol Genet. 2011 Feb 1;20(3):422-35. Epub 2010 Nov 3. (PubMed)

Fuchshofer R, Kottler UB, Ohlmann AV, Schloetzer-Schrehardt U, Juenemann A, Kruse FE, Ohlmann A.
SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro.
Mol Vis. 2011 Jan 19;17:177-85. (PubMed)

Kroeber M, Davis N, Holzmann S, Kritzenberger M, Shelah-Goraly M, Ofri R, Ashery-Padan R, Tamm ER. Reduced Expression of Pax6 in Lens and Cornea of Mutant Mice Leads to Failure of Chamber Angle Development and Juvenile Glaucoma. Hum Mol Genet. 2010 Jun 10. (PubMed)

Finzsch M, Schreiner S, Kichko T, Reeh P, Tamm ER, Bösl MR, Meijer D, Wegner M. Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010 May 17;189(4):701-12. (PubMed)

Seitz R, Hackl S, Seibuchner T, Tamm ER, Ohlmann A. Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/beta-catenin signaling pathway and the induction of neuroprotective growth factors in Muller cells. J Neurosci. 2010 Apr 28;30(17):5998-6010. (PubMed)

Ohlmann A, Seitz R, Braunger B, Seitz D, Bösl MR, Tamm ER. (2010). Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. J Neurosci. 2010 Jan 6;30(1):183-93.(PubMed)

Konz DD, Flügel-Koch C, Ohlmann A, Tamm ER. Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (2009). Graefes Arch Clin Exp Ophthalmol. 2009 Dec;247(12):1643-9. Epub 2009 Aug 7. (PubMed)

Goldwich A, Scholz M, Tamm ER. (2009). Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells. Histochem Cell Biol. 2009 Feb;131(2):167-80. Epub 2008 Oct 15. (PubMed)

Wolf L.V., Yang Y., Wang J., Xie Q., Braunger B., Tamm E.R., Zavadil J., Cvekl A. (2009). Identification of pax6-dependent gene regulatory networks in the mouse lens. PLoS ONE 4, e4159. (PubMed)

Tamm E.R., Ethier C.R. (2009). Current aspects of aqueous humor dynamics and glaucoma. Exp. Eye Res. 88. 618-9. (PubMed)

Tamm E.R. (2009). The trabecular meshwork outflow pathways: structural and functional aspects. Exp Eye Res. 88, 648-55 (PubMed)

Fuchshofer R., Tamm E.R. (2009). Modulation of extracellular matrix turnover in the trabecular meshwork. Exp. Eye Res. 88, 683-8 (PubMed)

Fuchshofer R., Stephan D.A., Russell P., Tamm E.R. (2009). Gene expression profiling of TGFβ2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-β2 signaling. Exp. Eye Res. 88, 1020-32 (PubMed)

Junglas B., Yu A.H.L., Welge-Lüssen U., Tamm E.R. Fuchshofer R. (2009). Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells. Exp. Eye Res. 88, 1065-75 (PubMed)

Davis N., Yoffe C., Raviv S., Antes R., Berger J., Holzmann S., Stoykova A., Overbeek P.A., Tamm E.R., Ashery-Padan R. (2009). Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol. 2009 Sep 1;333(1):132-42. Epub 2009 Jun 27 (PubMed)

Tamm E.R. (2008). Molecular Approaches to Glaucoma: Intriguing Clues for Pathology. In: Current Topics in Membranes, The Eye’s Aqueous Humor (Ed. Civan M.M.). Elsevier Inc.  pp. 379-425.

Tamm E.R. (2008). The Functional Role of Myocilin in Glaucoma. In: Ophthalmology Research: Mechanisms of the Glaucomas (Eds. Shields M.B., Tombran-Tink J., Barnstable C.J.). Humana Press, Totowa, NJ, pp. 219-231.

Tamm E.R., Kellenberger A. (2008). Aqueous Humor Dynamics and Trabecular Meshwork. In: Eye, Retina, and Visual System of the Mouse. III Organization of the Adult Mouse Eye and Central Visual System (Eds. Chalupa L.M., Williams R.W.). MIT Press, p. 129-33.

Paper W, Kroeber M, Heersink S, Stephan DA, Fuchshofer R, Russell P, Tamm ER. (2008). Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp. Eye Res. 87:257-67. (PubMed)

Wurm A., Sock E., Fuchshofer R., Wegner M., Tamm E.R. (2008). Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp. Eye Res., 86:895-907. (PubMed)

Janssen A, Hoellenriegel J, Fogarasi M, Schrewe H, Seeliger M, Tamm E, Ohlmann A, May CA, Weber BH, Stöhr H. (2008). Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest. Ophthalmol. Vis. Sci.;49:2812-22. (PubMed)

Tamm ER, Fuchshofer R. What Increases Outflow Resistance in Primary Open-angle Glaucoma? Surv Ophthalmol. 2007 Nov;52(6 Suppl):S101-4. (PubMed)

Pirity MK, Wang WL, Wolf LV, Tamm ER, Schreiber-Agus N, Cvekl A. Rybp, a polycomb complex-associated protein, is required for mouse eye development. BMC Dev Biol. 2007 Apr 30;7:39. (PubMed)

Fuchshofer R, Yu AH, Welge-Lussen U, Tamm ER. Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):715-26. (PubMed)

Russell P, Walsh E, Chen W, Goldwich A, Tamm ER. The effect of temperature on gene silencing by siRNAs: implications for silencing in the anterior chamber of the eye. Exp Eye Res. 2006 Jun;82(6):1011-6. (PubMed)

Kroeber M, Ohlmann A, Russell P, Tamm ER. Transgenic studies on the role of optineurin in the mouse eye. Exp Eye Res. 2006 Jun;82(6):1075-85. (PubMed)

Hinz B, Rosch S, Ramer R, Tamm ER, Brune K. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. FASEB J. 2005 Nov;19(13):1929-31. (PubMed)

Ricard CS, Tamm ER. Focus on Molecules: Myocilin/TIGR.
Exp Eye Res. 2005 Nov;81(5):501-2. (PubMed)

Davis-Silberman N, Kalich T, Oron-Karni V, Marquardt T, Kroeber M, Tamm ER,
Ashery-Padan R. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet. 2005 Aug 1;14(15):2265-76. (PubMed)

Gottanka J, Kirch W, Tamm ER. The origin of extrinsic nitrergic axons supplying the human eye. J Anat. 2005 Mar;206(3):225-9. (PubMed)

Ohlmann A., Scholz M., Goldwich A., Chauhan B.K., Hudl K., Ohlmann A.V., Zrenner E., Berger W., Cvekl A., Seeliger M.W., Tamm E.R. (2005). Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. J. Neurosci. 2005 25, 1701-1710. (PubMed)

Friedrich R.P., Schlierf B., Tamm E.R., Bosl M.R., Wegner M. (2005) The class III POU domain protein Brn-1 can fully replace the related Oct-6 during Schwann cell development and myelination. Mol. Cell. Biol. 25, 1821-9. (PubMed)

Zillig M., Wurm A., Grehn F.J., Russell P., Tamm E.R. (2005) Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Invest. Ophthalmol. Vis. Sci. 46, 223-34. (PubMed)

Goldwich A., Baulmann D.C., Ohlmann A., Flügel-Koch C., Schöcklmann H., Tamm E.R. (2005). Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis. Kidney Int., 67, 140-151. (PubMed)

Tamm E.R., Carassa R.G., Albert D.M., Gabelt B.T., Patel S., Rasmussen C.A., Kaufman P.L. (2004). Viscocanalostomy in rhesus monkeys. Arch. Ophthalmol., 122, 1826-1838. (PubMed)

Flügel-Koch C., Ohlmann A., Fuchshofer R., Welge-Lüssen U., Tamm E.R. (2004). Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. Exp. Eye Res., 79, 649-663. (PubMed)

Sock E., Rettig S.D., Enderich J., Bosl M.R., Tamm E.R., Wegner M. (2004) Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol. Cell Biol., 24, 6635-6644. (PubMed)

Cvekl A., Tamm E.R. (2004). Anterior eye development and ocular mesenchyme: New insights from mouse models and human diseases. Bioessays, 26, 378-386. (PubMed)

Knaupp, C., Flügel-Koch C., Goldwich A., Ohlmann, A., Tamm E.R. (2004) The expression of myocilin during murine eye development. Graefe’s Arch. Clin. Exp. Ophthalmol., 242, 339-45 . (PubMed)

Santas A.J., Bahler C., Peterson J.A., Filla M.S., Kaufman P.L., Tamm E.R., Johnson D., Peters D.P. (2003). The heparin II domain of fibronectin modulates aqueous outflow in cultured anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci., 44, 4796-4804. (PubMed)

Rhee, D.J., Tamm, E.R., and Russell, P. (2003) Donor corneoscleral buttons: A new source of trabecular meshwork for research. Exp. Eye Res., 77, 749-756. (PubMed)

Ohlmann A., Goldwich A., Flügel-Koch C., Fuchs A.V., Schwager K., Tamm E.R. (2003). The secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves. Glia, 43, 128-140. (PubMed)

Goldwich A., Ethier C.R., Chan D. W.-H., Tamm E.R. (2003). Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest. Opthalmol. Vis. Sci., 44, 1953-1961. (PubMed)

Baulmann D., Ohlmann A., Flügel-Koch C., Goswami S., Cvekl A., Tamm E.R. (2002). Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities. Mech. Develop. 118, 3-17. (PubMed)

Flügel-Koch C., Ohlmann A., Piatigorsky J., Tamm E.R. (2002). Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev. Dyn. 225, 111-125. (PubMed)

Weber B.H.W., Schrewe H., Molday L.L., Gehrig A., White K.L., Seeliger M.W., Jaissle G.B., Friedburg C., Tamm E., Molday R.S. (2002). Inactivation of the murine X-linked juvenile retinoschisis gene, rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. PNAS, 99, 6222-6227. (PubMed)

Rao V., Wawrousek E., Tamm E.R., Zigler S. Jr. (2002). Rho GTPase inactivation impairs lens growth and integrity. Lab. Invest. 82, 231-239. (PubMed)

Borrás T., Rowlette L.L.S., Tamm E.R., Gottanka J., Epstein D.L. (2002). Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. Invest. Ophthalmol. Vis. Sci. 43, 33-40. (PubMed)

Tamm E.R. (2002). Myocilin and glaucoma. Facts and ideas. Prog. Ret. Eye Res. 21, 395-428. (PubMed)

Ohlmann A., Tamm E.R. (2002). Die Rolle von Myocilin bei der Pathogenese des primären Offenwinkelglaukoms. Der Ophthalmologe, 99, 672-677. (Springer)

Tamm E.R., Polansky J. (2001). The TIGR/MYOC gene and glaucoma: opportunities for new understandings. J. Glaucoma, 10(Suppl 1), S9-S12. (PubMed)

Brady J.P., Garland D.L., Green D.E., Tamm E.R., Giblin F., Wawrousek E.F. (2001). aB-Crystallin is not essential for development of a transparent lens but may be critical for muscle integrity. Invest. Ophthalmol. Vis. Sci., 42, 2924-2932. (PubMed)

Maihöfner C., Schlötzer-Schrehardt U., Gühring H., Zeilhofer H.U., Naumann G.O.H., Tamm E.R., Brune K. (2001). Specific loss of ciliary COX-2 expression in patients with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci., 42, 2616-2624. 

Russell P., Tamm E.R., Grehn F.J., Picht G., Johnson M. (2001). The presence and properties of myocilin in the aqueous humor. Invest. Ophthalmol. Vis. Sci., 42, 983-986. (PubMed)

Tamm E.R., Russell, P. (2001) The Role of Myocilin/TIGR in Glaucoma. Results of the Glaucoma Research Foundation Catalyst Meeting in Berkeley, CA, March 2000. J. Glaucoma, 10, 329-339. (PubMed)

Piatigorsky J., Kozmik Z., Horwitz J., Ding L., Carosa E., Robison W.G.Jr., Steinbach P.J., Tamm E.R. (2000). Omega-crystallin of the scallop lens. A dimeric aldehyde dehydogenase class 1/2 enzyme-crystallin. J. Biol. Chem. 275, 41064-41073. (PubMed)

Kirstein L., Cvekl A., Chauhan B.K., Tamm E.R. (2000). Regulation of human myocilin/TIGR gene transcripton in trabecular meshwork cells and astrocytes: Role of upstream stimulatory factor. Genes Cells, 5, 661-676. (PubMed)

Karali A., Russell P., Stefani F.H., Tamm E.R. (2000). Localization of myocilin/ trabecular meshwork inducible glucocorticoid response protein in the human eye. Invest. Opthalmol. Vis. Sci., 41, 729-740. (PubMed)